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Conference Paper: Relapse predictors in frist-episode schizophrenia: a 3-year longitudinal study

TitleRelapse predictors in frist-episode schizophrenia: a 3-year longitudinal study
Authors
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
The 20th International Congress on Schizophrenia Research (ICSR 2005), Savannah, GA., 2-6 April 2005. In Schizophrenia Bulletin, 2005, v. 31 n. 2, p. 219 How to Cite?
AbstractThe relapsing nature of schizophrenia poses great challenge in terms of treatment and recovery. Identification of relapse predictors would be of utmost importance and relevance in the management of schizophrenia. In this naturalistic study, potential relapse predictors in terms of demographics, clinical symptomatology and cognition were investigated. 153 consecutive patients with first-episode psychosis were recruited, of which 138 fulfilled DSM-IV criteria for schizophrenia, schizophreniform disorder or schizoaffective disorder upon review at 3 years. Of the 138 eligible subjects, 93 completed the study at 3 years. They were 42 men and 51 women with a mean age of 31.2 (S.D.= 9.6), mean duration of untreated psychosis of 474 days (S.D.= 768), and mean educational attainment of 10.54 years (S.D.=2.9). 55 patients (605) experienced no relapse at 3 years, 25 (27%) had one relapse and 12 (13%) had 2 or more relapses. Those who relapsed have significantly poorer medication adherence (year 1: t=-3.4, p=0.002; year 2: t=-3.6, p=0.001; year 3: t=-3.4, p=0.002) and lower age at presentation (t=3.27, p=0.002). They also tended to have more life events prior to onset (t=-1.687, p=0.097) and more years of education (t=-1.99, p=0.049). No significant effect was found with regard to pre-morbid personality and gender. Our findings suggest that medication adherence and younger age at presentation are significant predictors of the number of relapses in first-episode schizophrenia patients in the first three years. Efforts should target at enhancing medication adherence and engagement of patients, especially those of younger age.
Persistent Identifierhttp://hdl.handle.net/10722/105445
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051

 

DC FieldValueLanguage
dc.contributor.authorChiu, CP-
dc.contributor.authorChen, EYH-
dc.contributor.authorLaw, CW-
dc.contributor.authorHui, CLM-
dc.contributor.authorChan, RC-
dc.contributor.authorDunn, ELW-
dc.contributor.authorMiao, YK-
dc.contributor.authorYeung, WS-
dc.contributor.authorWong, CK-
dc.contributor.authorChan, WF-
dc.contributor.authorTang, OWN-
dc.date.accessioned2010-09-25T22:34:26Z-
dc.date.available2010-09-25T22:34:26Z-
dc.date.issued2005-
dc.identifier.citationThe 20th International Congress on Schizophrenia Research (ICSR 2005), Savannah, GA., 2-6 April 2005. In Schizophrenia Bulletin, 2005, v. 31 n. 2, p. 219-
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/105445-
dc.description.abstractThe relapsing nature of schizophrenia poses great challenge in terms of treatment and recovery. Identification of relapse predictors would be of utmost importance and relevance in the management of schizophrenia. In this naturalistic study, potential relapse predictors in terms of demographics, clinical symptomatology and cognition were investigated. 153 consecutive patients with first-episode psychosis were recruited, of which 138 fulfilled DSM-IV criteria for schizophrenia, schizophreniform disorder or schizoaffective disorder upon review at 3 years. Of the 138 eligible subjects, 93 completed the study at 3 years. They were 42 men and 51 women with a mean age of 31.2 (S.D.= 9.6), mean duration of untreated psychosis of 474 days (S.D.= 768), and mean educational attainment of 10.54 years (S.D.=2.9). 55 patients (605) experienced no relapse at 3 years, 25 (27%) had one relapse and 12 (13%) had 2 or more relapses. Those who relapsed have significantly poorer medication adherence (year 1: t=-3.4, p=0.002; year 2: t=-3.6, p=0.001; year 3: t=-3.4, p=0.002) and lower age at presentation (t=3.27, p=0.002). They also tended to have more life events prior to onset (t=-1.687, p=0.097) and more years of education (t=-1.99, p=0.049). No significant effect was found with regard to pre-morbid personality and gender. Our findings suggest that medication adherence and younger age at presentation are significant predictors of the number of relapses in first-episode schizophrenia patients in the first three years. Efforts should target at enhancing medication adherence and engagement of patients, especially those of younger age.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletin-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleRelapse predictors in frist-episode schizophrenia: a 3-year longitudinal study-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0586-7614&volume=31&spage=219&epage=&date=2005&atitle=Relapse+Predictors+in+Frist-episode+Schizophrenia+-+A+3-year+Longitudinal+Studyen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.emailLaw, CW: lawcw@hkucc.hku.hk-
dc.identifier.emailHui, CLM: h0007716@graduate.hku.hk-
dc.identifier.emailDunn, ELW: dunnlw@HKUSUA.hku.hk-
dc.identifier.authorityChen, EYH=rp00392-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.doi10.1093/schbul/sbi024-
dc.identifier.hkuros104397-
dc.identifier.hkuros104433-
dc.identifier.volume31-
dc.identifier.issue2-
dc.identifier.spage219-
dc.identifier.epage219-
dc.publisher.placeUnited Kingdom-

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