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Conference Paper: Expression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach

TitleExpression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomach
Authors
Issue Date2004
PublisherAmerican Association for Cancer Research
Citation
AACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 978-979 Abstract no. 4242 How to Cite?
AbstractBackground and aims: CDX2 and Li-cadherin are intestinal specific markers that are normally only found in small intestine and colon. CDX2 is a caudal-related homeobox transcription factor that regulates intestinal development, differentiation and maintenance of the intestinal phenotype. It regulates Li-cadherin in colorectal cell line model, HT29. Since a step-wise progression from normal mucosa through gastritis, intestinal metaplasia and dysplasia to adenocarcinoma has been suggested for gastric cancer, we hypothesized that the intestinal markers CDX2 and Li-cadherin might be expressed in gastric cancer. The aim of this study is to investigate the expression of CDX2 and Li-cadherin in gastric cancer. Methods: 80 pairs of tumor and adjacent non-cancerous gastric mucosa were collected from gastrectomy specimens. Semi-quantitative RT-PCR was utilized to study the mRNA expression levels of CDX2 and Li-cadherin. Protein expression levels of CDX2 and Li-cadherin were determined by immunohistochemical staining. Results: The mRNA of CDX2 (56%) and Li-cadherin (70%) were over-expressed in tumor as compared to adjacent non-cancerous mucosa. Over-expression of Li-cadherin was significantly associated with CDX2. Over-expression of CDX2 and Li-cadherin were found to be associated with lymph node metastasis (p < 0.05). Immunohistochemical staining indicated that the expression of CDX2 and Li-cadherin were strongly co-localized in intestinal metaplasia and adenocarcinoma but absent in normal gastric mucosa. Conclusions: Over-expression of CDX2 and Li-cadherin was found in gastric adenocarcinoma. Expression of CDX2 and Li-cadherin were associated with lymph node metastasis. The co-localization of CDX2 and Li-cadherin during intestinal metaplasia may suggest a role in gastric carcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/104568
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorKo, Sen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorLuk, JMCen_HK
dc.contributor.authorWong, WYen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2010-09-25T21:58:23Z-
dc.date.available2010-09-25T21:58:23Z-
dc.date.issued2004en_HK
dc.identifier.citationAACR 95th Annual Meeting, Orlando FL, 27–31 March 2004. In Cancer Research, 2004, v. 64 n. 7S, p. 978-979 Abstract no. 4242-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/104568-
dc.description.abstractBackground and aims: CDX2 and Li-cadherin are intestinal specific markers that are normally only found in small intestine and colon. CDX2 is a caudal-related homeobox transcription factor that regulates intestinal development, differentiation and maintenance of the intestinal phenotype. It regulates Li-cadherin in colorectal cell line model, HT29. Since a step-wise progression from normal mucosa through gastritis, intestinal metaplasia and dysplasia to adenocarcinoma has been suggested for gastric cancer, we hypothesized that the intestinal markers CDX2 and Li-cadherin might be expressed in gastric cancer. The aim of this study is to investigate the expression of CDX2 and Li-cadherin in gastric cancer. Methods: 80 pairs of tumor and adjacent non-cancerous gastric mucosa were collected from gastrectomy specimens. Semi-quantitative RT-PCR was utilized to study the mRNA expression levels of CDX2 and Li-cadherin. Protein expression levels of CDX2 and Li-cadherin were determined by immunohistochemical staining. Results: The mRNA of CDX2 (56%) and Li-cadherin (70%) were over-expressed in tumor as compared to adjacent non-cancerous mucosa. Over-expression of Li-cadherin was significantly associated with CDX2. Over-expression of CDX2 and Li-cadherin were found to be associated with lymph node metastasis (p < 0.05). Immunohistochemical staining indicated that the expression of CDX2 and Li-cadherin were strongly co-localized in intestinal metaplasia and adenocarcinoma but absent in normal gastric mucosa. Conclusions: Over-expression of CDX2 and Li-cadherin was found in gastric adenocarcinoma. Expression of CDX2 and Li-cadherin were associated with lymph node metastasis. The co-localization of CDX2 and Li-cadherin during intestinal metaplasia may suggest a role in gastric carcinogenesis.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleExpression of CDX2 and LI-cadherin in intestinal metaplasia and adenocarcinoma of the stomachen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hkucc.hku.hken_HK
dc.identifier.emailYuen, ST: styuen@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.identifier.hkuros92273en_HK

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