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Conference Paper: Enhanced precursor B cell apoptosis in the bone marrow of CSF-1-deficient OP/OP mice

TitleEnhanced precursor B cell apoptosis in the bone marrow of CSF-1-deficient OP/OP mice
Authors
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI
Citation
The 11th International Congress of Immunology, Stockholm, Sweden, 22-27th July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl s1, abstract no. C4.Tue.1.6/138 How to Cite?
AbstractOsteopetrotic (op/op) mice are deficient in macrophages and osteoclasts due to a CSF-1 gene mutation. This study aimed to evaluate the effect of these deficiencies and of CSF-1-dependent mechanisms on B lymphopoiesis in bone marrow. B cell development and apoptoses have been examined in bone marrow of op/op mice, using immuno-fluorescence labeling and flow cytometry. Bone marrow cellularity was greatly reduced in op/op mice compared with normal littermates. However, precursor B cells were disproportionately decreased, most markedly at the pre-B cell stage. Precursor B cells displayed elevated apoptotic incidences both ex vivo and in short-term culture. Addition of recombinant CSF-1 reduced the incidence of apoptosis among precursor B cells in short-term cultures of whole bone marrow suspensions from normal mice but not in cultures of sorted B lineage cells. The findings provide evidence that CSF-1-dependent mechanisms can strongly influence the survival of precursor B cells in mouse bone marrow. It is proposed that the local or systemic levels of CSF-1 during ontogeny may thus play a role in regulating B cell production within the bone marrow microenvironment.
DescriptionThis FREE journal suppl. entitled: 11th International Congress of Immunology Stockholm, Sweden 22-27th July 2001
Abstracts - Tuesday 24th July 2001: no. C4.Tue.1.6/138
Persistent Identifierhttp://hdl.handle.net/10722/104513
ISSN
2015 Impact Factor: 2.27
2015 SCImago Journal Rankings: 0.934

 

DC FieldValueLanguage
dc.contributor.authorLu, Len_HK
dc.contributor.authorOsmond, D.G.en_HK
dc.date.accessioned2010-09-25T21:56:08Z-
dc.date.available2010-09-25T21:56:08Z-
dc.date.issued2001en_HK
dc.identifier.citationThe 11th International Congress of Immunology, Stockholm, Sweden, 22-27th July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl s1, abstract no. C4.Tue.1.6/138en_HK
dc.identifier.issn0300-9475en_HK
dc.identifier.urihttp://hdl.handle.net/10722/104513-
dc.descriptionThis FREE journal suppl. entitled: 11th International Congress of Immunology Stockholm, Sweden 22-27th July 2001-
dc.descriptionAbstracts - Tuesday 24th July 2001: no. C4.Tue.1.6/138-
dc.description.abstractOsteopetrotic (op/op) mice are deficient in macrophages and osteoclasts due to a CSF-1 gene mutation. This study aimed to evaluate the effect of these deficiencies and of CSF-1-dependent mechanisms on B lymphopoiesis in bone marrow. B cell development and apoptoses have been examined in bone marrow of op/op mice, using immuno-fluorescence labeling and flow cytometry. Bone marrow cellularity was greatly reduced in op/op mice compared with normal littermates. However, precursor B cells were disproportionately decreased, most markedly at the pre-B cell stage. Precursor B cells displayed elevated apoptotic incidences both ex vivo and in short-term culture. Addition of recombinant CSF-1 reduced the incidence of apoptosis among precursor B cells in short-term cultures of whole bone marrow suspensions from normal mice but not in cultures of sorted B lineage cells. The findings provide evidence that CSF-1-dependent mechanisms can strongly influence the survival of precursor B cells in mouse bone marrow. It is proposed that the local or systemic levels of CSF-1 during ontogeny may thus play a role in regulating B cell production within the bone marrow microenvironment.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJIen_HK
dc.relation.ispartofScandinavian Journal of Immunologyen_HK
dc.rightsScandinavian Journal of Immunology. Copyright © Blackwell Publishing Ltd.en_HK
dc.titleEnhanced precursor B cell apoptosis in the bone marrow of CSF-1-deficient OP/OP miceen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9475&volume=54&spage=Suppl 1.6&epage=&date=2001&atitle=Increased+pre-B+cell+apoptosis+in+CSF-1+deficient op/op+mutant+miceen_HK
dc.identifier.emailLu, L: liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-3083.2001.0540s1002.x-
dc.identifier.hkuros115488en_HK
dc.identifier.volume54en_HK
dc.identifier.issuesuppl s1-

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