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Conference Paper: Tensin2 with growth suppression and apoptosis induction activities is underexpressed in hepatocellular carcinoma

TitleTensin2 with growth suppression and apoptosis induction activities is underexpressed in hepatocellular carcinoma
Authors
Issue Date2008
PublisherAmerican Association for Cancer Research
Citation
The 99th AACR Annual Meeting, San Diego, CA, 12-16 April 2008. In Cancer Research, 2008, v. 68 n. 9S, p. 1770 How to Cite?
AbstractTensin is a family of focal adhesion proteins that strategically located among the extracellular matrix, actin cytoskeleton and signal transduction. Dysregulation of tensin members has been implicated in various human cancers. Accumulating evidence has shown that different members of tensin family are interacting partners of tumor suppressor, Deleted in liver cancer (DLC). Our recent study has identified tensin2 as the interacting partner of DLC1 and tensin2 itself exerted pronounced growth suppressive activity in hepatocellular carcinoma (HCC) cells. In the present study, we aimed to elucidate the role of tensin2 in hepatocarcinogenesis by determining the expression of tensin2 in human HCC tissues and ectopically expressing tensin2 in HCC cell line. Quantitative analysis of tensin2 expression revealed that it was underexpressed in 40% of human HCC. HCC cells stably expressing tensin2 displayed lower proliferation rate, decreased anchorage-independent growth, inhibited motility and invasiveness as compared with the vector transfectants. In addition, ectopic expression of tensin2 in HCC cells caused a dramatic suppression of colony formation and triggered apoptosis. The regulatory PTEN and SH2 domains were responsible for the biological activity of tensin2. In conclusion, our study showed that tensin2 was underexpressed in HCC and suggested the potential negative regulatory role of tensin2 in hepatocarcinogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/104482
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorYam, JWPen_HK
dc.contributor.authorTse, YTen_HK
dc.contributor.authorKo, CFen_HK
dc.contributor.authorChan, LKen_HK
dc.contributor.authorSze, MFen_HK
dc.contributor.authorNg, IOLen_HK
dc.date.accessioned2010-09-25T21:54:53Z-
dc.date.available2010-09-25T21:54:53Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 99th AACR Annual Meeting, San Diego, CA, 12-16 April 2008. In Cancer Research, 2008, v. 68 n. 9S, p. 1770-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/104482-
dc.description.abstractTensin is a family of focal adhesion proteins that strategically located among the extracellular matrix, actin cytoskeleton and signal transduction. Dysregulation of tensin members has been implicated in various human cancers. Accumulating evidence has shown that different members of tensin family are interacting partners of tumor suppressor, Deleted in liver cancer (DLC). Our recent study has identified tensin2 as the interacting partner of DLC1 and tensin2 itself exerted pronounced growth suppressive activity in hepatocellular carcinoma (HCC) cells. In the present study, we aimed to elucidate the role of tensin2 in hepatocarcinogenesis by determining the expression of tensin2 in human HCC tissues and ectopically expressing tensin2 in HCC cell line. Quantitative analysis of tensin2 expression revealed that it was underexpressed in 40% of human HCC. HCC cells stably expressing tensin2 displayed lower proliferation rate, decreased anchorage-independent growth, inhibited motility and invasiveness as compared with the vector transfectants. In addition, ectopic expression of tensin2 in HCC cells caused a dramatic suppression of colony formation and triggered apoptosis. The regulatory PTEN and SH2 domains were responsible for the biological activity of tensin2. In conclusion, our study showed that tensin2 was underexpressed in HCC and suggested the potential negative regulatory role of tensin2 in hepatocarcinogenesis.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleTensin2 with growth suppression and apoptosis induction activities is underexpressed in hepatocellular carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hken_HK
dc.identifier.emailSze, MF: szekaren@yahoo.comen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.authorityYam, JWP=rp00468en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.hkuros147197en_HK
dc.identifier.hkuros156772-

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