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Conference Paper: The relationship of insulin resistance, obesity and sleep-disordered breathing

TitleThe relationship of insulin resistance, obesity and sleep-disordered breathing
Authors
Issue Date2004
PublisherWiley-Blackwell Publishing Asia
Citation
The 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10-13 December 2004. In Respirology, 2004, v. 9 n. S3, p. A143 Abstract no. 291 How to Cite?
AbstractBackground Obesity, in particular abdominal obesity, is an established determinant of insulin resistance. There is growing evidence supporting a causal contribution of OSA on insulin resistance (1,2), independent of obesity. This prospective cohort study further investigated the relationship of abdominal fat, insulin resistance and sleep apnea. Methods Subjects were recruited from our sleep laboratory. Demographic and anthropometric data were collected. Overnight 16-channel polysomnography was performed. Insulin resistance was estimated by the Short insulin tolerance test (SITT), and was indicated by the rate of decline in blood glucose (K constant). Fasting serum cortisol and lipid profile (cholesterol, triglyceride, LDL & HDLcholesterol, fatty acid, Apolipoproteins A & B) were measured. Overnight 12-hour urine was collected to measure catecholamines. MRI scan of abdomen was performed to quantify the amount of visceral and subcutaneous fat at three levels of the abdomen. The Results 55 men, aged 21–65, BMI 27.2+/-4.6, AHI 30.1+/-5.2 were recruited. There were significant linear relationships of insulin resistance with AHI, arousal index, O2sat < 90%, urinary norepinephrine, waist circumference, BMI, body fat, HDL-cholesterol and triglyceride (P < 0.05). Multiple linear regression analysis showed that AHI (P < 0.001) and abdominal fat (P < 0.001)/waist circumference (P < 0.005)/BMI (P < 0.001) were independent predictors of insulin resistance. Conclusion Sleep disordered breathing reflected by AHI was a determinant of insulin resistance, independent of obesity reflected by detailed quantification of body fat. The findings further support a causal role of sleep apnea on insulin resistance. References 1 Ip M.S.M., Lam B., Ng M.M., et al. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002;165(5):670–6. 2 Punjabi N.M., Sorkin J.D., Katzel L.I., et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002;165(5):677–82. This project was supported by the Lee Wing Tat Cardiorespiratory Research Grant, The University of Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/102984
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157

 

DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorOoi, CGCen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-09-25T20:52:50Z-
dc.date.available2010-09-25T20:52:50Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10-13 December 2004. In Respirology, 2004, v. 9 n. S3, p. A143 Abstract no. 291en_HK
dc.identifier.issn1323-7799-
dc.identifier.urihttp://hdl.handle.net/10722/102984-
dc.description.abstractBackground Obesity, in particular abdominal obesity, is an established determinant of insulin resistance. There is growing evidence supporting a causal contribution of OSA on insulin resistance (1,2), independent of obesity. This prospective cohort study further investigated the relationship of abdominal fat, insulin resistance and sleep apnea. Methods Subjects were recruited from our sleep laboratory. Demographic and anthropometric data were collected. Overnight 16-channel polysomnography was performed. Insulin resistance was estimated by the Short insulin tolerance test (SITT), and was indicated by the rate of decline in blood glucose (K constant). Fasting serum cortisol and lipid profile (cholesterol, triglyceride, LDL & HDLcholesterol, fatty acid, Apolipoproteins A & B) were measured. Overnight 12-hour urine was collected to measure catecholamines. MRI scan of abdomen was performed to quantify the amount of visceral and subcutaneous fat at three levels of the abdomen. The Results 55 men, aged 21–65, BMI 27.2+/-4.6, AHI 30.1+/-5.2 were recruited. There were significant linear relationships of insulin resistance with AHI, arousal index, O2sat < 90%, urinary norepinephrine, waist circumference, BMI, body fat, HDL-cholesterol and triglyceride (P < 0.05). Multiple linear regression analysis showed that AHI (P < 0.001) and abdominal fat (P < 0.001)/waist circumference (P < 0.005)/BMI (P < 0.001) were independent predictors of insulin resistance. Conclusion Sleep disordered breathing reflected by AHI was a determinant of insulin resistance, independent of obesity reflected by detailed quantification of body fat. The findings further support a causal role of sleep apnea on insulin resistance. References 1 Ip M.S.M., Lam B., Ng M.M., et al. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002;165(5):670–6. 2 Punjabi N.M., Sorkin J.D., Katzel L.I., et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 2002;165(5):677–82. This project was supported by the Lee Wing Tat Cardiorespiratory Research Grant, The University of Hong Kong.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofRespirologyen_HK
dc.titleThe relationship of insulin resistance, obesity and sleep-disordered breathingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailTam, S: stam@HKUCC.hku.hken_HK
dc.identifier.emailLai, AYK: agneslai@HKUCC.hku.hken_HK
dc.identifier.emailTsang, KWT: kwttsang@hku.hken_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1843.2004.00673.x-
dc.identifier.hkuros98152en_HK
dc.identifier.volume9en_HK
dc.identifier.issueS3en_HK
dc.identifier.spageA143en_HK

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