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Conference Paper: Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study

TitleEradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study
Authors
Issue Date2002
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
The 2002 Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association (AGA), San Francisco, CA.,19–22 May 2002. In Gastroenterology, 2002, v. 122 n. suppl. 4, p. A588, abstract no. W1215 How to Cite?
AbstractAIMS: To examine the effects of H. pytori eradication on gastric precancerous lesions in a high risk population in China. METHOD: 2423 healthy individuals aged 35 to 65 were recruited in Changle (standardized mortality rate of gastric cancer in males- 153/100,000), Fujian, China for a screening endoscopic study in 1994. Patients without endoscopic lesions and positive for H. pylori infection by rapid urease test and histology (n=1628) were randomized to receive two-week course of omeprazole, amoxycillin/clavulanate and metronidazole (n = 819) or placebo (n = 809). Upper endoscopy was performed with biopsy specimens obtained from the antrum and corpus at baseline and repeated in 1999. 927 subjects had available (pre / post) histology for evaluation (508 in triple group and 419 in placebo group). Histological assessment was performed according to Updated Sydney Classification by a single blinded pathologist. Patients were graded according to advancing stages of gastritis, gastric atrophy, intestinal metaplasia and dysplasia. Progression or regression in histology required at least one grade higher or lower respectively. RESULT: The age, sex distribution and mean baseline histologic scores were similar between the two groups. CONCLUSION: H. pylori eradication slowed the progression of gastric atrophy at both antrum and the corpus significantly; and slowed the progression of intestinal metaplasia in corpus only. H. pylori eradication is beneficial in halting the progression of gastric precancerous lesions in high risk population at 5-year follow-up.
Persistent Identifierhttp://hdl.handle.net/10722/102832
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorWong, BCY-
dc.contributor.authorLam, SK-
dc.contributor.authorWong, RWM-
dc.contributor.authorFeng, RE-
dc.contributor.authorZheng, T-
dc.contributor.authorYuen, ST-
dc.contributor.authorHo, JCY-
dc.contributor.authorLeung, SY-
dc.contributor.authorChen, JS-
dc.contributor.authorLai, KC-
dc.date.accessioned2010-09-25T20:46:37Z-
dc.date.available2010-09-25T20:46:37Z-
dc.date.issued2002-
dc.identifier.citationThe 2002 Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association (AGA), San Francisco, CA.,19–22 May 2002. In Gastroenterology, 2002, v. 122 n. suppl. 4, p. A588, abstract no. W1215-
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/102832-
dc.description.abstractAIMS: To examine the effects of H. pytori eradication on gastric precancerous lesions in a high risk population in China. METHOD: 2423 healthy individuals aged 35 to 65 were recruited in Changle (standardized mortality rate of gastric cancer in males- 153/100,000), Fujian, China for a screening endoscopic study in 1994. Patients without endoscopic lesions and positive for H. pylori infection by rapid urease test and histology (n=1628) were randomized to receive two-week course of omeprazole, amoxycillin/clavulanate and metronidazole (n = 819) or placebo (n = 809). Upper endoscopy was performed with biopsy specimens obtained from the antrum and corpus at baseline and repeated in 1999. 927 subjects had available (pre / post) histology for evaluation (508 in triple group and 419 in placebo group). Histological assessment was performed according to Updated Sydney Classification by a single blinded pathologist. Patients were graded according to advancing stages of gastritis, gastric atrophy, intestinal metaplasia and dysplasia. Progression or regression in histology required at least one grade higher or lower respectively. RESULT: The age, sex distribution and mean baseline histologic scores were similar between the two groups. CONCLUSION: H. pylori eradication slowed the progression of gastric atrophy at both antrum and the corpus significantly; and slowed the progression of intestinal metaplasia in corpus only. H. pylori eradication is beneficial in halting the progression of gastric precancerous lesions in high risk population at 5-year follow-up.-
dc.languageeng-
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro-
dc.relation.ispartofGastroenterology-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleEradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=122 &issue=4 suppl 1&spage=A588&epage=&date=2002&atitle=Eradication+of+Helicobacter+pylori+infection+significantly+slows+down+the+progression+of+precancerous+lesions+in+high+risk+population:+a+5-year+prospective+randomized+studyen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hk-
dc.identifier.emailLam, SK: hrmelsk@hkucc.hku.hk-
dc.identifier.emailWong, RWM: wmwongg@hku.hk-
dc.identifier.emailYuen, ST: styuen@hkucc.hku.hk-
dc.identifier.emailHo, JCY: jennyho@hku.hk-
dc.identifier.emailLeung, SY: suetyi@hkucc.hku.hk-
dc.identifier.emailLai, KC: kclai@hku.hk-
dc.identifier.authorityWong, BCY=rp00429-
dc.identifier.authorityLeung, SY=rp00359-
dc.identifier.doi10.1016/S0016-5085(02)83888-4-
dc.identifier.hkuros73107-
dc.identifier.volume122-
dc.identifier.issuesuppl. 4-
dc.identifier.spageA588, abstract no. W1215-
dc.identifier.epageA588, abstract no. W1215-
dc.publisher.placeUnited States-

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