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Conference Paper: A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versis cefazolin plus ceftazidime in the treatment of CAPD peritonitis

TitleA randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versis cefazolin plus ceftazidime in the treatment of CAPD peritonitis
Authors
Issue Date2005
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
The 3rd World Congress of Nephrology, Singapore, 26-30 June 2005. In Nephrology, 2005 v. 10 suppl. 1, p. A68, abstract no. M-PO40056 How to Cite?
DescriptionSession: Peritoneal Dialysis – Infections: no. M-PO40056
Persistent Identifierhttp://hdl.handle.net/10722/102760
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894

 

DC FieldValueLanguage
dc.contributor.authorLui, SLen_HK
dc.contributor.authorCheng, SWen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorYip, PCen_HK
dc.contributor.authorTse, KCen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLo, WKen_HK
dc.date.accessioned2010-09-25T20:43:43Z-
dc.date.available2010-09-25T20:43:43Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 3rd World Congress of Nephrology, Singapore, 26-30 June 2005. In Nephrology, 2005 v. 10 suppl. 1, p. A68, abstract no. M-PO40056en_HK
dc.identifier.issn1320-5358en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102760-
dc.descriptionSession: Peritoneal Dialysis – Infections: no. M-PO40056-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEPen_HK
dc.relation.ispartofNephrologyen_HK
dc.titleA randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versis cefazolin plus ceftazidime in the treatment of CAPD peritonitisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1320-5358&volume=10 &issue=suppl&spage=A68&epage=&date=2005&atitle=A+randomized+prospective+comparison+of+intraperitoneal+cefazolin+plus+netilimicin+versis+cefazolin+plus+ceftazidime+in+the+treatment+of+CAPD+peritonitisen_HK
dc.identifier.emailLui, SL: sllui@HKUCC.hku.hken_HK
dc.identifier.emailCheng, SW: sukwaicheng@yahoo.com.hken_HK
dc.identifier.emailNg, EHY: nghye@hkucc.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLo, WK: wkloc@HKUCC.hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1797.2005.00419.x-
dc.identifier.hkuros121560en_HK
dc.identifier.volume10en_HK
dc.identifier.issuesupplen_HK
dc.identifier.issuesuppl. 1-
dc.identifier.spage68en_HK
dc.identifier.spageA68, abstract no. M-PO40056-
dc.identifier.epageA68, abstract no. M-PO40056-
dc.deduplication.noteBACKGROUND: The ISPD guidelines for the treatment of CAPD peritonitis 2000 recommended the use of cefazolin plus ceftazidime (C + C) as the initial empiric treatment. However, this regime has not been compared with the conventional regime of cefazolin plus netilmicin (C + N) in prospective randomized trials. AIM: To compare the efficacy of intraperitoneal (i.p.) C + N versus C + C in the treatment of peritonitis complicating CAPD. METHODS: This is a prospective randomized open-label study. CAPD patients who developed clinical evidence of peritonitis were randomized to receive either i.p. C + Nor i.p. C + C, given once daily in the long dwell. The duration of treatment was 14 days. Patients who failed to respond to the assigned antibiotics were allowed to switch antibiotics according to the peritoneal fluid bacterial culture results. RESULTS: One hundred stable CAPD patients were recruited into the study. The mean age of the patients was 65 ± 13.4 years (range: 26–90). The mean duration of CAPD was 45.3 ± 47.5 months (range: 1–240). Forty-nine patients were randomized to receive C + N while 51 patients were randomized to receive C + C The culture positive rate for the C + Nand the C + C groups was 79.6% and 76.5% respectively. The primary response rate to the assigned antibiotic regimes for the C + N and the C + C groups was 63.2% and 64.7% respectively (P = NS). The overall cure rate for the two treatment groups was 81.6% and 82.3% respectively (P = NS). Seven patients from each of the two treatment groups failed to respond to i.p. antibiotic treatment and required removal of their peritoneal dialysis catheters. Relapse of CAPD peritonitis occurred in two patients from both treatment groups. CONCLUSIONS: We conclude that C + N and C + C have similar efficacy in the treatment of peritonitis complicating CAPD.-

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