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Conference Paper: Prevalence of metronidazole resistant Helicobacter pylori (Hp) strains among the Chinese peptic ulcer disease patients and normals in Hong Kong

TitlePrevalence of metronidazole resistant Helicobacter pylori (Hp) strains among the Chinese peptic ulcer disease patients and normals in Hong Kong
Authors
Issue Date1995
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week and the 95th Annual Meeting of the American Gastroenterological Association, San Diego, CA, 14–17 May 1995. In Gastroenterology, 1995, v. 108 n. 4 S1, p. A71 How to Cite?
AbstractWe have recently investigated the prevalence of metronidazole resistant (MR) and metronidazole sensitive (MS) Hp strains among our peptic ulcer disease (PUD) patients and volunteers in Hong Kong. Antral biopsies (x2) were obtained for culture of Hp and sensitivity testing against metronidazole from 44 consecutive PUD (38 DU & 6 GU) patients (28 males [m], mean age 44.7 yrs; and 16 females [f], mean age 56.4 yrs), 26 (25 DU & 1 GU) post eradication therapy (16 m, mean age 47.8 yrs; 10 f, mean age 52.7 yrs), and 51 asymptomatic volunteers (N, 23 m, mean age 49.1 yrs; 28 f, mean age 60.6 yrs) who were recruited from medical exhibitions. The sensitivity and specificity of culture results were calculated with reference to CLO test, anti-Hp ELISA or histology results. Chi-square or Fisher exact test was used for statistical analysis. Results The sensitivity and specificity of culture for Hp was 87% and 100% respectively. All the PUD patients were Hp+. 6/26 post eradication treatment patients were still Hp +, having missed by culture but diagnosed by CLO test &/or histology. There was singificantly higher MR Hp in the N than the PUD group (p =0.0007). There was no significant difference in the MR Hp between the m and the f in either the PUD (p=0.052) or the N (p=0.19) group. But, the overall MR Hp was significantly higher in f than in m (p =0.005). Conclusions Iust over 50% of the Hp is MR in I-Iong Kong. The frequency of MR Hp strains in the N population (80%) is approx, double that of the PUD patients (38.6%). Overall, they are more frequent in f than in m. MR does not seem to correlate with ulcerogenic potential.
Persistent Identifierhttp://hdl.handle.net/10722/102698
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChing, CKen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorLeung, KPen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorOng, Len_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLau, G-
dc.date.accessioned2010-09-25T20:41:12Z-
dc.date.available2010-09-25T20:41:12Z-
dc.date.issued1995en_HK
dc.identifier.citationDigestive Disease Week and the 95th Annual Meeting of the American Gastroenterological Association, San Diego, CA, 14–17 May 1995. In Gastroenterology, 1995, v. 108 n. 4 S1, p. A71en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102698-
dc.description.abstractWe have recently investigated the prevalence of metronidazole resistant (MR) and metronidazole sensitive (MS) Hp strains among our peptic ulcer disease (PUD) patients and volunteers in Hong Kong. Antral biopsies (x2) were obtained for culture of Hp and sensitivity testing against metronidazole from 44 consecutive PUD (38 DU & 6 GU) patients (28 males [m], mean age 44.7 yrs; and 16 females [f], mean age 56.4 yrs), 26 (25 DU & 1 GU) post eradication therapy (16 m, mean age 47.8 yrs; 10 f, mean age 52.7 yrs), and 51 asymptomatic volunteers (N, 23 m, mean age 49.1 yrs; 28 f, mean age 60.6 yrs) who were recruited from medical exhibitions. The sensitivity and specificity of culture results were calculated with reference to CLO test, anti-Hp ELISA or histology results. Chi-square or Fisher exact test was used for statistical analysis. Results The sensitivity and specificity of culture for Hp was 87% and 100% respectively. All the PUD patients were Hp+. 6/26 post eradication treatment patients were still Hp +, having missed by culture but diagnosed by CLO test &/or histology. There was singificantly higher MR Hp in the N than the PUD group (p =0.0007). There was no significant difference in the MR Hp between the m and the f in either the PUD (p=0.052) or the N (p=0.19) group. But, the overall MR Hp was significantly higher in f than in m (p =0.005). Conclusions Iust over 50% of the Hp is MR in I-Iong Kong. The frequency of MR Hp strains in the N population (80%) is approx, double that of the PUD patients (38.6%). Overall, they are more frequent in f than in m. MR does not seem to correlate with ulcerogenic potential.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titlePrevalence of metronidazole resistant Helicobacter pylori (Hp) strains among the Chinese peptic ulcer disease patients and normals in Hong Kongen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=108&spage=A71&epage=&date=1995&atitle=Prevalence+of+metronidazole+resistant+Helicobacter+pylori+(Hp)+strains+among+the+Chinese+peptic+ulcer+disease+patients+and+normals+in+Hong+Kongen_HK
dc.identifier.emailChing, CK: chi_kong_ching@hotmail.comen_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailLai, KC: kclai@HKUCC.hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/0016-5085(95)22946-9-
dc.identifier.hkuros9658en_HK
dc.identifier.volume108en_HK
dc.identifier.spageA71en_HK

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