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Conference Paper: Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in helicobacter pylori-infected gastric antrum, incisura and body: a useful marker for antralization

TitleAberrant epithelial expression of trefoil family factor 2 and mucin 6 in helicobacter pylori-infected gastric antrum, incisura and body: a useful marker for antralization
Authors
Issue Date2003
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal of Gastroenterology and Hepatology, v. 18 n. suppl. S2, p. B108, abstract no. 215 How to Cite?
AbstractBACKGROUND: Trefoil family factors (TFF), a group of small secretory peptides, and mucins, the major components of the mucous viscous gel covering the epithelial surface, play an important role in mucosal defense and healing. H. pylori infection causes gastric mucosal inflammation and injury. This study aimed to To determine the expression of TFF2 and MUC6 in normal and H. pylori infected gastric epithelium at the gastric antrum, incisura and body, and to explore the association between the aberrant expression of TFF2 and MUC6 and antralization in the incisura. METHODS: Gastric biopsy specimens taken from the gastric antrum, incisura and body of 76 patients with dyspeptic and reflux symptoms were examined by immunohistochemistry for TFF2 and MUC6 expression in the gastric foveola and deeper glands. H. pylori infection was determined by both a rapid urease test and histology. RESULTS: Of the 76 patients, 27 were positive for H. pylori infection. In the foveola,TFF2 and MUC6 expression, were significantly greater in positive patients with infection, than in H. pylori negative patients at the antrum (59.3% vs. 4.1%, OR = 34.2, 95% CI: 6.83–171.0, c2 = 29.30, P < 0.001, and 63.0% vs. 4.1%, OR = 40.0, 95%CI: 7.94–201.1, c2 = 32.19, P < 0.001, respectively) and the incisura (44.4% vs. 2.0% OR = 38.4, 95% CI: 4.61–320.2, c2 = 19.19, P < 0.001 and 48.1% vs. 0%, c2 = 25.17, P < 0.001, respectively). In the deeper glands, TFF2 and MUC6 expression was significantly higher in H. pylori infected patients than uninfected patients at the incisura (both 85.2% vs. 22.4%, OR = 19.9, 95% CI: 5.66–69.8, 27.71, P < 0.001, respectively). Antral type mucosa was present at the incisura in 36.8%) of patients. The rates of expression of TFF2 and MUC6 in the foveola were 39.3%, 5.9% and 0%, respectively, in antral type, transitional type and body type mucosa (df = 2, c2 = 43.74, P < 0.001). In the deeper glands, the rates were 92.9%, 23.5%, and 0%, respectively (df = 2, c2 = 15.62, P < 0.001). CONCLUSIONS: H. pylori infection increases the expression of TFF2 and MUC6 in the gastric epithelium, which may be a protective response of host to the mucosal damages induced by H. pylori infection. Over-expression of TFF2 and MUC6 is associated with antralization of gastric incisura, thus may be involved in and used as a biological marker for the process.
DescriptionSession - Upper GI/Hepatobilary
Persistent Identifierhttp://hdl.handle.net/10722/102501
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorYang, Y-
dc.contributor.authorXia, HHX-
dc.contributor.authorLam, SK-
dc.contributor.authorWong, RWM-
dc.contributor.authorCheung, KL-
dc.contributor.authorLeung, SY-
dc.contributor.authorYuen, ST-
dc.contributor.authorElia, G-
dc.contributor.authorWright, NA-
dc.contributor.authorWong, BCY-
dc.date.accessioned2010-09-25T20:33:12Z-
dc.date.available2010-09-25T20:33:12Z-
dc.date.issued2003-
dc.identifier.citationJournal of Gastroenterology and Hepatology, v. 18 n. suppl. S2, p. B108, abstract no. 215-
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/102501-
dc.descriptionSession - Upper GI/Hepatobilary-
dc.description.abstractBACKGROUND: Trefoil family factors (TFF), a group of small secretory peptides, and mucins, the major components of the mucous viscous gel covering the epithelial surface, play an important role in mucosal defense and healing. H. pylori infection causes gastric mucosal inflammation and injury. This study aimed to To determine the expression of TFF2 and MUC6 in normal and H. pylori infected gastric epithelium at the gastric antrum, incisura and body, and to explore the association between the aberrant expression of TFF2 and MUC6 and antralization in the incisura. METHODS: Gastric biopsy specimens taken from the gastric antrum, incisura and body of 76 patients with dyspeptic and reflux symptoms were examined by immunohistochemistry for TFF2 and MUC6 expression in the gastric foveola and deeper glands. H. pylori infection was determined by both a rapid urease test and histology. RESULTS: Of the 76 patients, 27 were positive for H. pylori infection. In the foveola,TFF2 and MUC6 expression, were significantly greater in positive patients with infection, than in H. pylori negative patients at the antrum (59.3% vs. 4.1%, OR = 34.2, 95% CI: 6.83–171.0, c2 = 29.30, P < 0.001, and 63.0% vs. 4.1%, OR = 40.0, 95%CI: 7.94–201.1, c2 = 32.19, P < 0.001, respectively) and the incisura (44.4% vs. 2.0% OR = 38.4, 95% CI: 4.61–320.2, c2 = 19.19, P < 0.001 and 48.1% vs. 0%, c2 = 25.17, P < 0.001, respectively). In the deeper glands, TFF2 and MUC6 expression was significantly higher in H. pylori infected patients than uninfected patients at the incisura (both 85.2% vs. 22.4%, OR = 19.9, 95% CI: 5.66–69.8, 27.71, P < 0.001, respectively). Antral type mucosa was present at the incisura in 36.8%) of patients. The rates of expression of TFF2 and MUC6 in the foveola were 39.3%, 5.9% and 0%, respectively, in antral type, transitional type and body type mucosa (df = 2, c2 = 43.74, P < 0.001). In the deeper glands, the rates were 92.9%, 23.5%, and 0%, respectively (df = 2, c2 = 15.62, P < 0.001). CONCLUSIONS: H. pylori infection increases the expression of TFF2 and MUC6 in the gastric epithelium, which may be a protective response of host to the mucosal damages induced by H. pylori infection. Over-expression of TFF2 and MUC6 is associated with antralization of gastric incisura, thus may be involved in and used as a biological marker for the process.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH-
dc.relation.ispartofJournal of Gastroenterology and Hepatology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. -
dc.titleAberrant epithelial expression of trefoil family factor 2 and mucin 6 in helicobacter pylori-infected gastric antrum, incisura and body: a useful marker for antralization-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=18&issue=Suppl&spage=B108&epage=&date=2003&atitle=Aberrant+epithelial+expression+of+trefoil+family+factor+2+and+mucin+6+in+Helicobacter+pylori-infected+gastric+antrum,+incisura+and+body:+a+useful+marker+for+antralizationen_HK
dc.identifier.emailXia, HHX: hhxxia@hku.hk-
dc.identifier.emailLam, SK: hrmelsk@hkucc.hku.hk-
dc.identifier.emailWong, RWM: wmwongg@hku.hk-
dc.identifier.emailLeung, SY: suetyi@hkucc.hku.hk-
dc.identifier.emailYuen, ST: styuen@hku.hk-
dc.identifier.emailWong, BCY: bcywong@hku.hk-
dc.identifier.authorityLeung, SY=rp00359-
dc.identifier.authorityWong, BCY=rp00429-
dc.identifier.doi10.1046/j.1440-1746.18.s2.9.x-
dc.identifier.hkuros99352-
dc.identifier.volume18-
dc.identifier.issuesuppl. S2-
dc.identifier.spageB108, abstract no. 215-
dc.identifier.epageB108, abstract no. 215-
dc.publisher.placeAustralia-

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