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Conference Paper: Increase in liver stiffness measurements in severe hepatitis B flares

TitleIncrease in liver stiffness measurements in severe hepatitis B flares
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The 43rd Annual Meeting of the European Association for the Study of the Liver (EASL 2008), Milan, Italy, 23–27 April 2008. In Journal of Hepatology, v. 48 suppl. 2, p. S242, abstract no. 649 How to Cite?
AbstractBACKGROUND: Liver stiffness measurement has been used as a non-invasive technique for assessing liver fibrosis. AIM: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors predictive of normal liver stiffness measurements after severe hepatitis METHODS: Patients with severe flare of hepatitis B as defined by ALT>10× upper limit of normal were included. Transient elastography was performed at time of flare (baseline), and at 3−6 months after flare. Normal liver stiffness measurement was defined as < 6kPa. Routine liver biochemistry was recorded. RESULTS: Thirty-eight patients with severe hepatitis B flare patients were included with a median age of 46 years (range, 20−73), of which 32 (84%) were male. At the time of flare, the median bilirubin, peak ALT, albumin, platelet, and prothrombin time were 41 umol/L (range, 5−778), 1543 U/L (range, 539–3000), 38 g/L (range, 23−49), 180 x 109/L (range, 47–341), and 12.9 s (10.6−24.6) respectively. The median liver stiffness was 18.5 kPa (range, 6.9−73.5), with no patients having normal liver stiffness. At 3−6 months, the median liver stiffness measurement of 8.4kPa (range, 4.4−25.1), and 10 (26%) patients had normalized their liver stiffness measurement. Thirty-six (95%) patients had a decrease in liver stiffness, with a median decline of 9.7kPa. The median ALT at 3−6 months was 31 U/L (range, 11−60), with 86% having normal ALT. Patients who had normal liver stiffness at 3−6 months had higher platelet count and lower prothrombin time at baseline compared to patients with persistently abnormal liver stiffness (230 vs 170 x 109/L, p = 0.025 and 12.2 vs 13.8 s, p = 0.034 respectively). There was significant correlation with ALT levels and liver stiffness (r = 0.64, p < 0.01). CONCLUSION: Liver stiffness was affected by severe hepatitis flares, with 95% having a decline, and over 25% normalizing their liver stiffness by 3−6 months. The significant correlation between ALT levels and liver stiffness suggests that increased liver stiffness in patients with severe flares is likely due to inflammation and not due to fibrosis. Factor associated with normalization of liver stiffness
DescriptionSession 05D. Viral Hepatitis – D) Hepatitis B – Clinical (Except Therapy) - Posters
This journal suppl. entitled: Abstracts of the 43 Annual Meeting of the European Association for the Study of the Liver
Persistent Identifierhttp://hdl.handle.net/10722/102359
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorBut, Den_HK
dc.contributor.authorHsu, Aen_HK
dc.contributor.authorCheng, CTKen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, RMFen_HK
dc.date.accessioned2010-09-25T20:27:28Z-
dc.date.available2010-09-25T20:27:28Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 43rd Annual Meeting of the European Association for the Study of the Liver (EASL 2008), Milan, Italy, 23–27 April 2008. In Journal of Hepatology, v. 48 suppl. 2, p. S242, abstract no. 649en_HK
dc.identifier.issn0168-8278en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102359-
dc.descriptionSession 05D. Viral Hepatitis – D) Hepatitis B – Clinical (Except Therapy) - Posters-
dc.descriptionThis journal suppl. entitled: Abstracts of the 43 Annual Meeting of the European Association for the Study of the Liver-
dc.description.abstractBACKGROUND: Liver stiffness measurement has been used as a non-invasive technique for assessing liver fibrosis. AIM: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors predictive of normal liver stiffness measurements after severe hepatitis METHODS: Patients with severe flare of hepatitis B as defined by ALT>10× upper limit of normal were included. Transient elastography was performed at time of flare (baseline), and at 3−6 months after flare. Normal liver stiffness measurement was defined as < 6kPa. Routine liver biochemistry was recorded. RESULTS: Thirty-eight patients with severe hepatitis B flare patients were included with a median age of 46 years (range, 20−73), of which 32 (84%) were male. At the time of flare, the median bilirubin, peak ALT, albumin, platelet, and prothrombin time were 41 umol/L (range, 5−778), 1543 U/L (range, 539–3000), 38 g/L (range, 23−49), 180 x 109/L (range, 47–341), and 12.9 s (10.6−24.6) respectively. The median liver stiffness was 18.5 kPa (range, 6.9−73.5), with no patients having normal liver stiffness. At 3−6 months, the median liver stiffness measurement of 8.4kPa (range, 4.4−25.1), and 10 (26%) patients had normalized their liver stiffness measurement. Thirty-six (95%) patients had a decrease in liver stiffness, with a median decline of 9.7kPa. The median ALT at 3−6 months was 31 U/L (range, 11−60), with 86% having normal ALT. Patients who had normal liver stiffness at 3−6 months had higher platelet count and lower prothrombin time at baseline compared to patients with persistently abnormal liver stiffness (230 vs 170 x 109/L, p = 0.025 and 12.2 vs 13.8 s, p = 0.034 respectively). There was significant correlation with ALT levels and liver stiffness (r = 0.64, p < 0.01). CONCLUSION: Liver stiffness was affected by severe hepatitis flares, with 95% having a decline, and over 25% normalizing their liver stiffness by 3−6 months. The significant correlation between ALT levels and liver stiffness suggests that increased liver stiffness in patients with severe flares is likely due to inflammation and not due to fibrosis. Factor associated with normalization of liver stiffness-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhepen_HK
dc.relation.ispartofJournal of Hepatologyen_HK
dc.rightsJournal of Hepatology. Copyright © Elsevier BV.en_HK
dc.titleIncrease in liver stiffness measurements in severe hepatitis B flaresen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8278&volume=48 &issue=Suppl 2&spage=S242&epage=&date=2008&atitle=Increase+in+liver+stiffness+measurements+in+severe+hepatitis+B+flaresen_HK
dc.identifier.emailFung, JYY: jfung@sicklehut.comen_HK
dc.identifier.emailCheng, CTK: ctkcheng@HKUCC.hku.hken_HK
dc.identifier.emailHung, IFN: ifnhung@yahoo.com.hken_HK
dc.identifier.emailSeto, WK: wkseto@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8278(08)60651-0-
dc.identifier.hkuros152609en_HK
dc.identifier.hkuros145373-
dc.identifier.volume48en_HK
dc.identifier.issuesuppl. 2en_HK
dc.identifier.spageS242, abstract no. 649en_HK
dc.identifier.epageS242, abstract no. 649-

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