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Conference Paper: Serum and spent dialysis fluid concentration of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in patient with peritonitis

TitleSerum and spent dialysis fluid concentration of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in patient with peritonitis
Authors
Issue Date2007
PublisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.com
Citation
The 3rd ISPD Asian Chapter Meeting - An International Conference on Dialysis Officially Endorsed by the International Society for Peritoneal Dialysis, Hiroshima, Japan, 22-24 November 2007. In Peritoneal Dialysis International, v. 27 suppl. 4, p. S47 How to Cite?
AbstractObjective: Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa glycoprotein that is highly inducible in a variety of epithelial cells during inflammation. In the present study, we examined level of NGAL in serum and spent peritoneal dialysis fluid (sPDF) from patients with peritonitis (P). Methods: Serum and sPDF were collected from patients as baseline before the onset of P. Once patients developed P, serum was collected on days 1, 7, and 42 whereas sPDF were collected on days 1, 3, 5, 7, and 14 after P. The concentrations of NGAL in serum and sPDF were determined by sandwich ELISA. Results: Serum NGAL concentration collected from patients on day 1 after P was significantly higher (p<0.01) than baseline. There was no significant difference in serum NGAL concentration among serum collected at baseline and that of day 7 and day 42 after P. There was positive correlation (p<0.05) between neutrophil count and serum NGAL concentration at all time points after P examined suggesting that neutrophils are the source of the raised circulatory NGAL levels after P. NGAL concentration in sPDF remained significantly higher (p<0.05) than baseline at the first 3 days after the P episode and was gradually decreased from day 5 onward. There was positive correlation (p<0.05) between NGAL concentration in PDF of P patients and the neutrophil count on days 1 and 3, but not on days 5, 7, 14, or 42 after P, suggesting neutrophils are the source of the raised NGAL levels in the PDF only in the first 3 day after P. There was no difference in NGAL concentration in the serum or sPDF between patients with gram-negative and gram-positive bacterial P. However, the NGAL concentration in sPDF from patient with culture-negative P was significantly lower than that from patients with gram-negative and gram-positive bacterial P. Conclusion: We have provided novel data on the concentration of NGAL in serum and spent PDF from patients with P. We hope these data can help in future elucidation of the role of NGAL in P.
DescriptionThis journal suppl. entitled: Abstracts of the Third Asian Chapter Meeting — ISPD An International Conference on Dialysis Officially Endorsed by the International Society for Peritoneal Dialysis ... 2007
Session - Peritoneal Physiology, Pathophysiology, and Inflammation
Persistent Identifierhttp://hdl.handle.net/10722/102316
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683

 

DC FieldValueLanguage
dc.contributor.authorLeung, JCKen_HK
dc.contributor.authorTang, SCWen_HK
dc.contributor.authorLam, MFen_HK
dc.contributor.authorChan, YYen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-25T20:25:43Z-
dc.date.available2010-09-25T20:25:43Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 3rd ISPD Asian Chapter Meeting - An International Conference on Dialysis Officially Endorsed by the International Society for Peritoneal Dialysis, Hiroshima, Japan, 22-24 November 2007. In Peritoneal Dialysis International, v. 27 suppl. 4, p. S47en_HK
dc.identifier.issn0896-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102316-
dc.descriptionThis journal suppl. entitled: Abstracts of the Third Asian Chapter Meeting — ISPD An International Conference on Dialysis Officially Endorsed by the International Society for Peritoneal Dialysis ... 2007-
dc.descriptionSession - Peritoneal Physiology, Pathophysiology, and Inflammation-
dc.description.abstractObjective: Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa glycoprotein that is highly inducible in a variety of epithelial cells during inflammation. In the present study, we examined level of NGAL in serum and spent peritoneal dialysis fluid (sPDF) from patients with peritonitis (P). Methods: Serum and sPDF were collected from patients as baseline before the onset of P. Once patients developed P, serum was collected on days 1, 7, and 42 whereas sPDF were collected on days 1, 3, 5, 7, and 14 after P. The concentrations of NGAL in serum and sPDF were determined by sandwich ELISA. Results: Serum NGAL concentration collected from patients on day 1 after P was significantly higher (p<0.01) than baseline. There was no significant difference in serum NGAL concentration among serum collected at baseline and that of day 7 and day 42 after P. There was positive correlation (p<0.05) between neutrophil count and serum NGAL concentration at all time points after P examined suggesting that neutrophils are the source of the raised circulatory NGAL levels after P. NGAL concentration in sPDF remained significantly higher (p<0.05) than baseline at the first 3 days after the P episode and was gradually decreased from day 5 onward. There was positive correlation (p<0.05) between NGAL concentration in PDF of P patients and the neutrophil count on days 1 and 3, but not on days 5, 7, 14, or 42 after P, suggesting neutrophils are the source of the raised NGAL levels in the PDF only in the first 3 day after P. There was no difference in NGAL concentration in the serum or sPDF between patients with gram-negative and gram-positive bacterial P. However, the NGAL concentration in sPDF from patient with culture-negative P was significantly lower than that from patients with gram-negative and gram-positive bacterial P. Conclusion: We have provided novel data on the concentration of NGAL in serum and spent PDF from patients with P. We hope these data can help in future elucidation of the role of NGAL in P.-
dc.languageengen_HK
dc.publisherMultimed, Inc. The Journal's web site is located at http://pdiconnect.comen_HK
dc.relation.ispartofPeritoneal Dialysis Internationalen_HK
dc.titleSerum and spent dialysis fluid concentration of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in patient with peritonitisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0896-8608&volume=27&spage=S47&epage=&date=2007&atitle=Serum+and+spent+peritonitis+fluid+concentration+of+neutrophil+gelatinase-associated+lipocalin+(NGAL)+in+peritonitisen_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.emailTang, SCW: scwtang@hku.hken_HK
dc.identifier.emailChan, YY: yychanb@HKUCC.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, SCW=rp00480en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.hkuros139065en_HK
dc.identifier.volume27en_HK
dc.identifier.issuesuppl. 4-
dc.identifier.spageS47en_HK
dc.identifier.epageS47-

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