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Conference Paper: Association between adiponectin and endothelial dysfunction

TitleAssociation between adiponectin and endothelial dysfunction
Authors
Issue Date2003
PublisherElsevier Ireland Ltd.
Citation
The 13th International Symposium on Atherosclerosis, Kyoto, Japan, 28 September-2 October 2003. In Atherosclerosis Supplements, 2003, v. 4 n. 2, p. 57, abstract no. 1P-0167 How to Cite?
AbstractOBJECTIVE: Adiponectin is an adipocyte-specific plasma protein and recent evidence suggests that adiponectin may have an antiatherogenic effect by reducing endothelial activation. This study was performed to investigate whether plasma adiponectin levels were related to endothelial dysfunction in patients with or without type 2 diabetes. METHODS: 73 patients with type 2 diabetes and 73 matched controls of similar age and body mass index were recruited. Plasma adiponectin level was determined by an in-house RIA assay, using a rabbit polyclonal antibody against adiponectin. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high resolution vascular ultrasound. RESULTS: Plasma adiponectin level was reduced in the diabetic patients compared to controls (4.73 ± 1.96 µg/ml vs 7.69 ± 2.80 respectively, p < 0.001). Both endothelium-dependent (5.6 ± 3.6% vs 8.6 ± 4.5 respectively, p<0.001) and independent (13.3 ± 4.9% vs 16.5 ± 5.6 respectively, p < 0.001) vasodilation were impaired in the diabetic patients. On univariate analysis, plasma adiponectin levels correlated with endothelium-dependent vasodilation in the controls (r=0.26, p=0.02) and in the diabetic patients (r=0.24, p=0.04) whereas no significant relationship with endothelium-independent vasodilation was found. On multiple linear regression analysis, only gender, HbA1c and plasma adiponectin level were significant independent determinants of endothelium-dependent vasodilation. CONCLUSION: Low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation in subjects with or without type 2 diabetes. In addition to its role in glucose metabolism, adiponectin may act as a link between adipose tissue and the vasculature.
Persistent Identifierhttp://hdl.handle.net/10722/102172
ISSN
2015 Impact Factor: 3.356
2015 SCImago Journal Rankings: 1.240

 

DC FieldValueLanguage
dc.contributor.authorTan, KCB-
dc.contributor.authorXu, A-
dc.contributor.authorChow, WS-
dc.contributor.authorAi, VHG-
dc.contributor.authorTam, SCF-
dc.contributor.authorLam, KSL-
dc.date.accessioned2010-09-25T20:19:56Z-
dc.date.available2010-09-25T20:19:56Z-
dc.date.issued2003-
dc.identifier.citationThe 13th International Symposium on Atherosclerosis, Kyoto, Japan, 28 September-2 October 2003. In Atherosclerosis Supplements, 2003, v. 4 n. 2, p. 57, abstract no. 1P-0167-
dc.identifier.issn1567-5688-
dc.identifier.urihttp://hdl.handle.net/10722/102172-
dc.description.abstractOBJECTIVE: Adiponectin is an adipocyte-specific plasma protein and recent evidence suggests that adiponectin may have an antiatherogenic effect by reducing endothelial activation. This study was performed to investigate whether plasma adiponectin levels were related to endothelial dysfunction in patients with or without type 2 diabetes. METHODS: 73 patients with type 2 diabetes and 73 matched controls of similar age and body mass index were recruited. Plasma adiponectin level was determined by an in-house RIA assay, using a rabbit polyclonal antibody against adiponectin. Endothelium-dependent and independent vasodilation of the brachial artery was measured by high resolution vascular ultrasound. RESULTS: Plasma adiponectin level was reduced in the diabetic patients compared to controls (4.73 ± 1.96 µg/ml vs 7.69 ± 2.80 respectively, p < 0.001). Both endothelium-dependent (5.6 ± 3.6% vs 8.6 ± 4.5 respectively, p<0.001) and independent (13.3 ± 4.9% vs 16.5 ± 5.6 respectively, p < 0.001) vasodilation were impaired in the diabetic patients. On univariate analysis, plasma adiponectin levels correlated with endothelium-dependent vasodilation in the controls (r=0.26, p=0.02) and in the diabetic patients (r=0.24, p=0.04) whereas no significant relationship with endothelium-independent vasodilation was found. On multiple linear regression analysis, only gender, HbA1c and plasma adiponectin level were significant independent determinants of endothelium-dependent vasodilation. CONCLUSION: Low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation in subjects with or without type 2 diabetes. In addition to its role in glucose metabolism, adiponectin may act as a link between adipose tissue and the vasculature.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd.-
dc.relation.ispartofAtherosclerosis Supplement-
dc.rightsPosting accepted manuscript (postprint): © 2003. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleAssociation between adiponectin and endothelial dysfunction-
dc.typeConference_Paper-
dc.identifier.emailTan, KCB: kcbtan@hku.hk-
dc.identifier.emailXu, A: amxu@hku.hk-
dc.identifier.emailChow, WS: chowws01@hkucc.hku.hk-
dc.identifier.emailAi, VHG: vhgai@hkucc.hku.hk-
dc.identifier.emailTam, SCF: stam@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityTan, KCB=rp00402-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityLam, KSL=rp00343-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1567-5688(03)90240-6-
dc.identifier.hkuros84950-
dc.identifier.volume4-
dc.identifier.issue2-
dc.identifier.spage57, abstract no. 1P-0167-
dc.identifier.epage57, abstract no. 1P-0167-
dc.publisher.placeIreland-

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