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Conference Paper: Mannose binding lectin polymorphisms and hepatitis B infection in Chinese

TitleMannose binding lectin polymorphisms and hepatitis B infection in Chinese
Authors
KeywordsMedical sciences
Allergology and immunology
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI
Citation
The 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842 How to Cite?
AbstractHepatitis B virus (HBV) infection is common in the Chinese. Mannose binding lectin (MBL) may recognize the mannose residues in the middle envelope of HBV and result in either direct opsonization or activation of lectin complement pathway. Serum MBL level is inuenced by the polymorphisms in exon 1 (codons 52, 54 and 57) and promoter (H/L alleles at -550 and X/Y alleles at -221). Allele B of codon 54 and promoter haplotype LX lead to low serum MBL level. We have previously shown that allele B is related to progression of HBV disease. In this study, serum MBL levels, frequencies of allele B and promoter haplotypes between the control group and HBV infected patients were compared. Blood samples of asymptomatic HBV patients (n=389) and symptomatic patients (n=205) (with cirrhosis or hepatocellular carcinoma) were collected. The median serum MBL levels of controls (1766_g/l, n=230), asymptomatic patients (1324_g/l, n=389) and symptomatic patients (877_g/l, n=205) are different (P<0.0001). The frequencies of allele B of controls (0.10, n=199), asymptomatic patients (0.15, n=384) and symptomatic patients (0.29, n=198) are also different (P<0.0001). Low serum MBL level and high frequency of allele B may be a risk factor for both progression of HBV infection and for becoming a carrier. Further data on association of promoter polymorphisms with HBV infection will also be discussed.
DescriptionTheme 4: Host-parasite interactions, innate immunity, reproductive and local immunity - W 4.7 Complement and collectins in the innate immune defence: abstract no. C15.Tue.4.7/842
Persistent Identifierhttp://hdl.handle.net/10722/102159
ISSN
2015 Impact Factor: 2.27
2015 SCImago Journal Rankings: 0.934

 

DC FieldValueLanguage
dc.contributor.authorTo, YFen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorPoon, TPen_HK
dc.contributor.authorIp, WKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-25T20:19:25Z-
dc.date.available2010-09-25T20:19:25Z-
dc.date.issued2001en_HK
dc.identifier.citationThe 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842en_HK
dc.identifier.issn0300-9475-
dc.identifier.urihttp://hdl.handle.net/10722/102159-
dc.descriptionTheme 4: Host-parasite interactions, innate immunity, reproductive and local immunity - W 4.7 Complement and collectins in the innate immune defence: abstract no. C15.Tue.4.7/842-
dc.description.abstractHepatitis B virus (HBV) infection is common in the Chinese. Mannose binding lectin (MBL) may recognize the mannose residues in the middle envelope of HBV and result in either direct opsonization or activation of lectin complement pathway. Serum MBL level is inuenced by the polymorphisms in exon 1 (codons 52, 54 and 57) and promoter (H/L alleles at -550 and X/Y alleles at -221). Allele B of codon 54 and promoter haplotype LX lead to low serum MBL level. We have previously shown that allele B is related to progression of HBV disease. In this study, serum MBL levels, frequencies of allele B and promoter haplotypes between the control group and HBV infected patients were compared. Blood samples of asymptomatic HBV patients (n=389) and symptomatic patients (n=205) (with cirrhosis or hepatocellular carcinoma) were collected. The median serum MBL levels of controls (1766_g/l, n=230), asymptomatic patients (1324_g/l, n=389) and symptomatic patients (877_g/l, n=205) are different (P<0.0001). The frequencies of allele B of controls (0.10, n=199), asymptomatic patients (0.15, n=384) and symptomatic patients (0.29, n=198) are also different (P<0.0001). Low serum MBL level and high frequency of allele B may be a risk factor for both progression of HBV infection and for becoming a carrier. Further data on association of promoter polymorphisms with HBV infection will also be discussed.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI-
dc.relation.ispartofScandinavian Journal of Immunologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectAllergology and immunology-
dc.titleMannose binding lectin polymorphisms and hepatitis B infection in Chineseen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9475&volume=54, suppl. 1, article no. C15.Tue.4.7/842&spage=W 4.7&epage=&date=2001&atitle=Mannose+binding+lectin+polymorphisms+and+hepatitis+B+infection+in+Chinese-
dc.identifier.emailTo, YF: h9603964@hkusua.hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailPoon, TP: poontp@hkucc.hku.hken_HK
dc.identifier.emailIp, WK: WIP@partners.orgen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-3083.2001.0540s1002.x-
dc.identifier.hkuros64997en_HK
dc.identifier.volume54en_HK
dc.identifier.issuesuppl. s1-
dc.identifier.spage65 (Tuesday)-
dc.identifier.epage65 (Tuesday)-
dc.publisher.placeUnited Kingdom-
dc.description.otherThe 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842-

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