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Conference Paper: Mannose binding lectin polymorphisms and hepatitis B infection in Chinese
Title | Mannose binding lectin polymorphisms and hepatitis B infection in Chinese |
---|---|
Authors | |
Keywords | Medical sciences Allergology and immunology |
Issue Date | 2001 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI |
Citation | The 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842 How to Cite? |
Abstract | Hepatitis B virus (HBV) infection is common in the Chinese. Mannose binding lectin (MBL) may recognize the mannose residues in the middle envelope of HBV and result in either direct opsonization or activation of lectin complement pathway. Serum MBL level is inuenced by the polymorphisms in exon 1 (codons 52, 54 and 57) and promoter (H/L alleles at -550 and X/Y alleles at -221). Allele B of codon 54 and promoter haplotype LX lead to low serum MBL level. We have previously shown that allele B is related to progression of HBV disease. In this study, serum MBL levels, frequencies of allele B and promoter haplotypes between the control group and HBV infected patients were compared. Blood samples of asymptomatic HBV patients (n=389) and symptomatic patients (n=205) (with cirrhosis or hepatocellular carcinoma) were collected. The median serum MBL levels of controls (1766_g/l, n=230), asymptomatic patients (1324_g/l, n=389) and symptomatic patients (877_g/l, n=205) are different (P<0.0001). The frequencies of allele B of controls (0.10, n=199), asymptomatic patients (0.15, n=384) and symptomatic patients (0.29, n=198) are also different (P<0.0001). Low serum MBL level and high frequency of allele B may be a risk factor for both progression of HBV infection and for becoming a carrier. Further data on association of promoter polymorphisms with HBV infection will also be discussed. |
Description | Theme 4: Host-parasite interactions, innate immunity, reproductive and local immunity - W 4.7 Complement and collectins in the innate immune defence: abstract no. C15.Tue.4.7/842 |
Persistent Identifier | http://hdl.handle.net/10722/102159 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 0.946 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | To, YF | en_HK |
dc.contributor.author | Yuen, MF | en_HK |
dc.contributor.author | Poon, TP | en_HK |
dc.contributor.author | Ip, WK | en_HK |
dc.contributor.author | Lai, CL | en_HK |
dc.contributor.author | Lau, YL | en_HK |
dc.date.accessioned | 2010-09-25T20:19:25Z | - |
dc.date.available | 2010-09-25T20:19:25Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | The 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842 | en_HK |
dc.identifier.issn | 0300-9475 | - |
dc.identifier.uri | http://hdl.handle.net/10722/102159 | - |
dc.description | Theme 4: Host-parasite interactions, innate immunity, reproductive and local immunity - W 4.7 Complement and collectins in the innate immune defence: abstract no. C15.Tue.4.7/842 | - |
dc.description.abstract | Hepatitis B virus (HBV) infection is common in the Chinese. Mannose binding lectin (MBL) may recognize the mannose residues in the middle envelope of HBV and result in either direct opsonization or activation of lectin complement pathway. Serum MBL level is inuenced by the polymorphisms in exon 1 (codons 52, 54 and 57) and promoter (H/L alleles at -550 and X/Y alleles at -221). Allele B of codon 54 and promoter haplotype LX lead to low serum MBL level. We have previously shown that allele B is related to progression of HBV disease. In this study, serum MBL levels, frequencies of allele B and promoter haplotypes between the control group and HBV infected patients were compared. Blood samples of asymptomatic HBV patients (n=389) and symptomatic patients (n=205) (with cirrhosis or hepatocellular carcinoma) were collected. The median serum MBL levels of controls (1766_g/l, n=230), asymptomatic patients (1324_g/l, n=389) and symptomatic patients (877_g/l, n=205) are different (P<0.0001). The frequencies of allele B of controls (0.10, n=199), asymptomatic patients (0.15, n=384) and symptomatic patients (0.29, n=198) are also different (P<0.0001). Low serum MBL level and high frequency of allele B may be a risk factor for both progression of HBV infection and for becoming a carrier. Further data on association of promoter polymorphisms with HBV infection will also be discussed. | - |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/SJI | - |
dc.relation.ispartof | Scandinavian Journal of Immunology | en_HK |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject | Medical sciences | - |
dc.subject | Allergology and immunology | - |
dc.title | Mannose binding lectin polymorphisms and hepatitis B infection in Chinese | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-9475&volume=54, suppl. 1, article no. C15.Tue.4.7/842&spage=W 4.7&epage=&date=2001&atitle=Mannose+binding+lectin+polymorphisms+and+hepatitis+B+infection+in+Chinese | - |
dc.identifier.email | To, YF: h9603964@hkusua.hku.hk | en_HK |
dc.identifier.email | Yuen, MF: mfyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Poon, TP: poontp@hkucc.hku.hk | en_HK |
dc.identifier.email | Ip, WK: WIP@partners.org | en_HK |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | en_HK |
dc.identifier.email | Lau, YL: lauylung@hkucc.hku.hk | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1046/j.1365-3083.2001.0540s1002.x | - |
dc.identifier.hkuros | 64997 | en_HK |
dc.identifier.volume | 54 | en_HK |
dc.identifier.issue | suppl. s1 | - |
dc.identifier.spage | 65 (Tuesday) | - |
dc.identifier.epage | 65 (Tuesday) | - |
dc.publisher.place | United Kingdom | - |
dc.description.other | The 11th International Congress of Immunology, Stockholm Convention Centre, Stochkolm, Sweden, 22-27 July 2001. In Scandinavian Journal of Immunology, 2001, v. 54 suppl. s1, p. 65 (Tuesday), abstract no. C15.Tue.4.7/842 | - |
dc.identifier.issnl | 0300-9475 | - |