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Conference Paper: Prevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management

TitlePrevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and management
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The 58th Annual Meeting of the American Association of the Study of Liver Diseases (AASLD), Boston, MA., 2-6 November 2007. In Hepatology, v. 46 n. 4 suppl. S1, p. 647A, abstract no. 922 How to Cite?
AbstractAIM: To document the prevalence and factors associated with severe fibrosis and cirrhosis in a large population of Asian chronic hepatitis B (CHB) patients. METHODS: Transient elastography was performed in unselected CHB patients using Fibroscan (Echosens, France). Liver stiffness score of >8.1 kPa was used as a cut-off for the presence of severe fibrosis or liver cirrhosis. Demographics and laboratory parameters were recorded. Results: A total of 951 patients were recruited, of which 605 (64%) were males, with median age of 43 years, and positive HBeAg in 226 (24%). Overall 319 (34%) had severe fibrosis, with higher prevalence seen in males compared with females (39% vs 24% respectively, p< 25 years to 81% in those >65 years. In patients who were ≤45 years of age, there was no significant difference in prevalence of severe fibrosis between HBeAg-positive and HBeAg-negative patients. After the age of 45 years, higher prevalence of severe fibrosis was seen in HBeAg(+) patients compared to HBeAg(-) patients (58% vs 43% respectively, p=0.03). There was also increasing prevalence of severe fibrosis with increasing ALT levels: in patients with ALT less than 0.5 x upper limit of normal (ULN) and 0.5-1 x ULN (11% vs 30% respectively, p5 x ULN. Higher prevalence of fibrosis was seen in patients with HBV DNA ≥4 log copies/ml compared to those below this level (41% vs 27% respectively …
DescriptionThis free journal suppl. entitled: AASLD Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/101990
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorFung, JYYen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorBut, Den_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorYuen, RMFen_HK
dc.date.accessioned2010-09-25T20:12:39Z-
dc.date.available2010-09-25T20:12:39Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 58th Annual Meeting of the American Association of the Study of Liver Diseases (AASLD), Boston, MA., 2-6 November 2007. In Hepatology, v. 46 n. 4 suppl. S1, p. 647A, abstract no. 922en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101990-
dc.descriptionThis free journal suppl. entitled: AASLD Abstracts-
dc.description.abstractAIM: To document the prevalence and factors associated with severe fibrosis and cirrhosis in a large population of Asian chronic hepatitis B (CHB) patients. METHODS: Transient elastography was performed in unselected CHB patients using Fibroscan (Echosens, France). Liver stiffness score of >8.1 kPa was used as a cut-off for the presence of severe fibrosis or liver cirrhosis. Demographics and laboratory parameters were recorded. Results: A total of 951 patients were recruited, of which 605 (64%) were males, with median age of 43 years, and positive HBeAg in 226 (24%). Overall 319 (34%) had severe fibrosis, with higher prevalence seen in males compared with females (39% vs 24% respectively, p< 25 years to 81% in those >65 years. In patients who were ≤45 years of age, there was no significant difference in prevalence of severe fibrosis between HBeAg-positive and HBeAg-negative patients. After the age of 45 years, higher prevalence of severe fibrosis was seen in HBeAg(+) patients compared to HBeAg(-) patients (58% vs 43% respectively, p=0.03). There was also increasing prevalence of severe fibrosis with increasing ALT levels: in patients with ALT less than 0.5 x upper limit of normal (ULN) and 0.5-1 x ULN (11% vs 30% respectively, p5 x ULN. Higher prevalence of fibrosis was seen in patients with HBV DNA ≥4 log copies/ml compared to those below this level (41% vs 27% respectively …-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_HK
dc.titlePrevalence of fibrosis and cirrhosis in chronic hepatitis B: implications for treatment and managementen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=46&issue=4&spage=647A&epage=&date=2007&atitle=Prevalence+of+fibrosis+and+cirrhosis+in+chronic+hepatitis+B:+implications+for+treatment+and+managementen_HK
dc.identifier.emailFung, JYY: jfung@sicklehut.comen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailCheung, TK: cheungtingkin@yahoo.comen_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.authorityFung, JYY=rp00518en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/hep.22020-
dc.identifier.hkuros145538en_HK
dc.identifier.hkuros152470-
dc.identifier.volume46en_HK
dc.identifier.issuesuppl. 1en_HK
dc.identifier.spage647A, abstract no. 922en_HK
dc.identifier.epage647A, abstract no. 922-

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