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Conference Paper: NMO-IgG in idiopathic inflammatory demyelinating disorders among Hong Kong Chinese

TitleNMO-IgG in idiopathic inflammatory demyelinating disorders among Hong Kong Chinese
Authors
Issue Date2008
PublisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/medicine/neurology/journal/415
Citation
The 18th Meeting of the European Neurological Society (ENS 2008), Nice, France, 7–11 June 2008. In Journal of Neurology, 2008, v. 225 suppl. 2, p. 208, abstract no. P836 How to Cite?
AbstractObjective: Neuromyelitis optica (NMO) is characterized by monophasic or recurrent attacks of acute transverse myelitis (ATM) and optica neuritis (ON). 73 % of Caucasian NMO patients are seropositive for the NMO-IgG which distinguishes NMO from classical multiple sclerosis (CMS). The NMO-IgG autoantigen is aquaporin-4 water channel. We aim to study the seropositivity rate of NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders (IIDD). Methods: Local IIDD patients (CMS, ATM [single or recurrent] without ON, ON [single/recurrent] without ATM, ATM with ON [monophasic or recurrent], acute disseminated encephalomyelitis [ADEM]) had sera taken at onset. Control sera were from healthy subjects, and patients with other neurological disorders (OND: stroke, Gullain-Barre syndrome, polymyositis, paraneoplastic neurological disorders).CMS was diagnosed according to revised McDonald’s criteria. Patients were followed up for at least 1 year. Sera from IIDD patients and controls were tested for NMO-IgG by indirect immunofluorescence using slides containing Monkey cerebellum and mouse gut tissues. Rabbit anti-aquaporin 4 antibody (Sigma) was used for positive control. Results: Three of 5 (60 %) non-CMS patients with ATM and ON were NMO-IgG positive. All 5 had extensive ATM, 4 of the 5 had severe visual impairment or paraplegia. Two of the 5 had brainstem dysfunction clinically with brainstem abnormalities on magnetic resonance imaging (MRI) brain; MRI brain was otherwise normal for all 5. All 5 were negative for cerebrospinal fluid oligoclonal bands.One of 25 (4 %) CMS patients was seropositive for NMO-IgG. Among 5 patients with recurrent ATM without ON, 3 were NMO-IgG positive and all 3 had recurrent extensive ATM (> 3 vertebral segments on MRI spine); one of the 2 NMO-IgG negative patients had recurrent extensive ATM with brainstem involvement, and one had recurrent ATM extending < 3 vertebral segments. None of patients with a single attack of ATM (8) or single/recurrent ON (11)were seropositive for NMO-IgG. None of the healthy subjects or patients with OND was NMO-IgG positive. Two patients with paraneoplastic cerebellar ataxia and breast cancer were seropositive for the Purkinje cell antibody type 1 (anti-Yo). Conclusion: 60 % of local patients with NMO or recurrent extensive ATM without ON were seropositive for NMO-IgG, while 4 % of CMS patients were seropositive. NMO-IgG is useful for diagnosis of NMO and recurrent extensive ATM without ON.
Persistent Identifierhttp://hdl.handle.net/10722/101711
ISSN
2015 Impact Factor: 3.408
2015 SCImago Journal Rankings: 1.429

 

DC FieldValueLanguage
dc.contributor.authorChan, KH-
dc.contributor.authorRamsden, DB-
dc.contributor.authorChu, ACY-
dc.contributor.authorKwok, KHH-
dc.contributor.authorHo, SL-
dc.date.accessioned2010-09-25T20:00:46Z-
dc.date.available2010-09-25T20:00:46Z-
dc.date.issued2008-
dc.identifier.citationThe 18th Meeting of the European Neurological Society (ENS 2008), Nice, France, 7–11 June 2008. In Journal of Neurology, 2008, v. 225 suppl. 2, p. 208, abstract no. P836-
dc.identifier.issn0340-5354-
dc.identifier.urihttp://hdl.handle.net/10722/101711-
dc.description.abstractObjective: Neuromyelitis optica (NMO) is characterized by monophasic or recurrent attacks of acute transverse myelitis (ATM) and optica neuritis (ON). 73 % of Caucasian NMO patients are seropositive for the NMO-IgG which distinguishes NMO from classical multiple sclerosis (CMS). The NMO-IgG autoantigen is aquaporin-4 water channel. We aim to study the seropositivity rate of NMO-IgG in local patients with idiopathic inflammatory demyelinating disorders (IIDD). Methods: Local IIDD patients (CMS, ATM [single or recurrent] without ON, ON [single/recurrent] without ATM, ATM with ON [monophasic or recurrent], acute disseminated encephalomyelitis [ADEM]) had sera taken at onset. Control sera were from healthy subjects, and patients with other neurological disorders (OND: stroke, Gullain-Barre syndrome, polymyositis, paraneoplastic neurological disorders).CMS was diagnosed according to revised McDonald’s criteria. Patients were followed up for at least 1 year. Sera from IIDD patients and controls were tested for NMO-IgG by indirect immunofluorescence using slides containing Monkey cerebellum and mouse gut tissues. Rabbit anti-aquaporin 4 antibody (Sigma) was used for positive control. Results: Three of 5 (60 %) non-CMS patients with ATM and ON were NMO-IgG positive. All 5 had extensive ATM, 4 of the 5 had severe visual impairment or paraplegia. Two of the 5 had brainstem dysfunction clinically with brainstem abnormalities on magnetic resonance imaging (MRI) brain; MRI brain was otherwise normal for all 5. All 5 were negative for cerebrospinal fluid oligoclonal bands.One of 25 (4 %) CMS patients was seropositive for NMO-IgG. Among 5 patients with recurrent ATM without ON, 3 were NMO-IgG positive and all 3 had recurrent extensive ATM (> 3 vertebral segments on MRI spine); one of the 2 NMO-IgG negative patients had recurrent extensive ATM with brainstem involvement, and one had recurrent ATM extending < 3 vertebral segments. None of patients with a single attack of ATM (8) or single/recurrent ON (11)were seropositive for NMO-IgG. None of the healthy subjects or patients with OND was NMO-IgG positive. Two patients with paraneoplastic cerebellar ataxia and breast cancer were seropositive for the Purkinje cell antibody type 1 (anti-Yo). Conclusion: 60 % of local patients with NMO or recurrent extensive ATM without ON were seropositive for NMO-IgG, while 4 % of CMS patients were seropositive. NMO-IgG is useful for diagnosis of NMO and recurrent extensive ATM without ON.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/medicine/neurology/journal/415-
dc.relation.ispartofJournal of Neurology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.titleNMO-IgG in idiopathic inflammatory demyelinating disorders among Hong Kong Chinese-
dc.typeConference_Paper-
dc.identifier.emailChan, KH: koonho@hkucc.hku.hk-
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk-
dc.identifier.authorityChan, KH=rp00537-
dc.identifier.authorityChu, ACY=rp00505-
dc.identifier.authorityHo, SL=rp00240-
dc.description.natureabstract-
dc.identifier.doi10.1007/s00415-008-2001-5-
dc.identifier.hkuros160922-
dc.identifier.volume225-
dc.identifier.issuesuppl. 2-
dc.identifier.spage208, abstract no. P836-
dc.identifier.epage208, abstract no. P836-
dc.publisher.placeGermany-

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