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Professor Li, Xuechen 李學臣

Title:
Professor
Associate Dean, Faculty of Science

Department:
Faculty of Science
Department of Chemistry

Faculty:
Faculty of Science

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
R5011-18Development of a colistin / adjuvant antimicrobial regimen that exhibits low toxicity and high efficacy in combating multidrug-resistant bacterial pathogens14284712018
 
17305615Towards the de novo synthesis of Pse; Total synthesis of P. aeruginosa strain 1244 pilin glycan7069722015
 
SRFS2324-7S01Chemical Protein Synthesis and New Applications Exploration77983802023
 
C7017-18GDevelopment of the glycosylated adiponectin collagenous domain as potential therapeutic agents for cancer and non-alcoholic fatty liver diseases42381302018
 
17303424Chemical synthesis and chemical biology studies of HMGB1 proteins with post-translational modifications9107422024
 
C6036-21GFrom Structural to Genomic Biology: A Multi-scale Approach Tightly Integrating Structural Biology and Novel Genomics Platform to Quantitatively Analyze the Transcription and its Regulation of SARS-Co V-2 Viral RNA Polymerase3000002021
 
C1024-22GMolecular Mechanism of RNA Transport and Specificity of their Spatial Distribution in Neuron620000
 
HKU 703811PDevelopment of chemoselective peptide ligation at serine and threonine sites and applications towards convergent syntheses of amyloid and fuzeon11757272011
 
HKU 707412PTowards Total Synthesis of Daptomycin and Its Analogues; Chemical Synthesis of Cyclic Peptides via Chemical Peptide Ligation8250002012
 
HKU 702813PChemical synthesis of the glycosylated adiponectin collagenous domain via serine/threonine ligation4659182013
 
13121182Development of daptomycin-based next-generation antibiotics to combat multidrug-resistant bacteria9980002013
 
17303920Chemoselective peptide cyclization development and application exploration6665122020
 
17309420Development of rapid-responsive carbapenemase sensors for tackling antibiotic resistance6665122020
 
202011033000302Development of novel cyclic peptide antibiotics against drug-resistant pathogens12560002020
 
T11-104/22-RMulti-disciplinary approaches to tackle the global public health threat of hypervirulent and multidrug-resistant Klebsiella pneumoniae2022
 
R1011-23Development of Bacterial Pseudaminic Acid-based Vaccine to Combat Infections caused by Multidrug Resistant Bacteria14285712023
 
C7038-15GTotal Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development50567202015
 
C6009-15GFrom Molecular Dynamics to Systems Biology: A Multi-scale Approach Tightly Integrating Simulation and Experiment to Quantitatively Analyze the Transcription Accuracy of RNA Polymerase II6000002015
 
C7147-20GDevelopment of glycopeptide-based anti SARS-CoV-2 vaccines59567432020
 
17309616Development of new methods and strategies for extending Ser/Thr ligation utility in protein chemical synthesis5408242016
 
PiH/197/22Development of Adiponectin-based Glycopeptides for Therapeutic Applications9659992021
 
PiH/196/22Development of Adiponectin-based Glycopeptides for Therapeutic Applications9659992021
 
PiH/195/22Development of Adiponectin-based Glycopeptides for Therapeutic Applications9659992021
 
C7003-20GIntegrative Chemical Biology Approaches to Investigate the Biological Process of Bacterial Pseudaminic Acid50500002020
 
21672180Chemical Synthesis of Adiponectin Glycoprotein and its Analogues8164002016
 
C5026-16GDevelopment of novel inhibitors targeting the resistance mechanisms of clinical superbugs15000002016
 
17303617Development of amine-specific reactions for peptide/protein modification and bioconjugation5228982017
 
N/ADeveloping next-generation antibiotics against multidrug resistant pathogens29560402018
 
17302621Development of Cysteine/Penicillamine ligation (CPL) and further explorations6660152021
 
22177097chemical synthesis and biological studies of caveolin-1 protein7912802021
 
20190802Development of synthetic carbohydrate-based antibacterial vaccines against Gram-negative bacteria13610002020
 
MRP/048/21XDevelopment of Adiponectin-based Glycopeptides for Therapeutic Applications52991422021
 
17303319Towards establishing the structure of antibiotic malacidin A via total synthesis5582722019
 
17312022Towards total synthesis of glycoproteins12068402022
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
20190442Synthesis of novel multifunctional nanocomposites based on biosurfactant coated Ag-MNPs/teixobactin analogues for enhanced biofilm disruption and bacteria elimination12015002020
 
17312822Chemical and biological studies of acinetaminic acid: a new non-2-ulosonic acid from the capsular polysaccharide of Acinetobacter baumannii8700002022
 
17306521Total Synthesis and In-depth Structural Modification of Klebsazolicin, An Antibiotic against Gram Negative Bacteria6660152021
 
C7005-20GDevelopment of DNA-encoded glycan constructs as multivalent influenza hemagglutinin inhibitors towards novel anti-influenza therapy49000002020
 
AoE/P-705/16Chemical Biology Approach to Molecular Medicine594240002016
 
17146216ω-Alkynyl arachidonic acid induces anti-inflammatory M2 polarization of macrophages in acute myocardial infarction via regulating the cross-talk between PKM2, iNOS and HIF-1α10889502016
 
19180692Decrypting the mechanism of anti-virulence compound HR3744 against MRSA by targeting the response regulator SaeR13496562019
 
AR170002Towards intervertebral disc repair by using novel small molecules that regulate proteoglycan metabolism8759782014
 
17119619Chinese medicine pentacyclic triterpene celastrol ameliorates inflammation, metabolic dysfunctions and insulin resistance in diet-induced obesity via covalently modifying endoplasmic reticulum chaperone GRP789281172019
 
12110772Lipoteichoic acid (LTA) of pathogenic Enterococcus faecalis modulates the functional characteristics of osteoblasts and osteoclasts7650002012
 
C7033-20GDeciphering the Physiological Functions and Regulation of the Endogenous CRISPR-Cas System for Biotechnological and Therapeutic Exploitations: Type I-F as a Paradigm52951032020
 
COVID190117Rapid development of anti-SARS-CoV-2 (2019-nCoV) vaccines and exploration of the feasibility of a Pancoronavirus vaccine32026882019
 
17300321Selection of DNA-encoded chemical library against protein targets with distal ligand-binding sites for multivalent ligand discovery9364152021
 
17120915Novel caffeic acid derivatives promote the phenotypic and functional switch of macrophages toward resolution of inflammation and cardiac regeneration after myocardial infarction10593112015
 
17100317Plant-derived celastrol ameliorates metabolic dysfunctions, oxidative stress and inflammation in diet-induced obesity via disrupting the cross-talk between PKM2, HIF-1α and IL-1β12290892017
 
HKU 775812MPharmacological induction of leukotriene B4 12-hydroxydehydrogenase (LTB4DH) for the resolution of neutrophil-induced myocardial injury11646052012
 
N/ATowards intervertebral disc repair by using novel small molecules that regulate proteoglycan metabolism9343142013
 
22210712Development of novel vaccine candidate and passive immunotherapy against multidrug-resistant hypervirulent Klebsiella pneumoniae14806842022
 
17101024Arresting caries with a novel antibacterial polymer fluoride15595802024
 
17308824Aromatic ortho-dialdehydes in polymer science: exploration of new polymerization chemistry and application-oriented functionalization study9107422024
 
JLFS/P-404/24Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis9375002024