Total Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development


Grant Data
Project Title
Total Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development
Principal Investigator
Dr Li, Xuechen   (Project coordinator)
Co-Investigator(s)
Dr Chen Sheng   (Co-principal investigator)
Duration
36
Start Date
2016-05-01
Completion Date
2019-04-30
Amount
4556720
Conference Title
Presentation Title
Keywords
cyclic peptides, antibacterial agents, bacterial resistance, chemical synthesis, medicinal chemistry
Discipline
Chemical Sciences,Microbiology
Panel
Physical Sciences
Sponsor
RGC Collaborative Research Fund (CRF)
HKU Project Code
C7038-15G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2015/2016
Status
On-going
Objectives
daptomycin-A54145 hybrid compounds. 2. Develop a total synthesis of mannopeptimycin and synthesize around 30 mannopeptimycin analogues for antibacterial screening. Establish its structure-activity relationship. 3. Develop a total synthesis of teixobactin and synthesize around 20 teixobactin analogues for antibacterial screening. Establish its structure-activity relationship. 4. Perform structural and functional characterization of cyclic peptide antibiotic analogues. 5. Evaluate the toxicity and in vivo activity of the synthesized analogues.