Total Synthesis and Medicinal Chemistry of Cyclic Peptide-based Antibacterial Compounds: An Integrative Programme for Novel Antibiotic Development
Dr Li, Xuechen (Project coordinator)
Dr Chen Sheng (Co-principal investigator)
cyclic peptides, antibacterial agents, bacterial resistance, chemical synthesis, medicinal chemistry
RGC Collaborative Research Fund (CRF)
HKU Project Code
Collaborative Research Fund (CRF) - Group Research Project
daptomycin-A54145 hybrid compounds. 2. Develop a total synthesis of mannopeptimycin and synthesize around 30 mannopeptimycin analogues for antibacterial screening. Establish its structure-activity relationship. 3. Develop a total synthesis of teixobactin and synthesize around 20 teixobactin analogues for antibacterial screening. Establish its structure-activity relationship. 4. Perform structural and functional characterization of cyclic peptide antibiotic analogues. 5. Evaluate the toxicity and in vivo activity of the synthesized analogues.