Towards the de novo synthesis of Pse; Total synthesis of P. aeruginosa strain 1244 pilin glycan
Dr Li, Xuechen (Principal investigator)
chemical glycosylation, bacterial glycan, total synthesis, glycopeptide
Physical Sciences (P)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
2 Study the chemical glycosylation of Pse. The diastereoselective glycosylation involving Pse has been reported to be very difficult. 3 Complete the total synthesis of P. aeruginosa 1244 pilin glycan-(alpha-5NβOHC4-7NFmPse-(2->4)-β-Xyl-(1->3)-β-FucNAc-β-Ser), which has not yet been reported. The presence of Pse and its β-linkage to xylose makes this synthesis very challenging. 4 Synthesize a glycopeptide containing alpha-5NβOHC4-7NFmPse-(2->4)-β-Xyl-(1->3)-β-FucNAc-β-Ser, which will lay the groundwork for synthesizing the full-length bacterial pilin glycoprotein (1-148).