Towards the de novo synthesis of Pse; Total synthesis of P. aeruginosa strain 1244 pilin glycan


Grant Data
Project Title
Towards the de novo synthesis of Pse; Total synthesis of P. aeruginosa strain 1244 pilin glycan
Principal Investigator
Dr Li, Xuechen   (Principal investigator)
Duration
36
Start Date
2015-10-01
Completion Date
2018-09-30
Amount
706972
Conference Title
Presentation Title
Keywords
chemical glycosylation, bacterial glycan, total synthesis, glycopeptide
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17305615
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 Study the chemical glycosylation of Pse. The diastereoselective glycosylation involving Pse has been reported to be very difficult. 3 Complete the total synthesis of P. aeruginosa 1244 pilin glycan-(alpha-5NβOHC4-7NFmPse-(2->4)-β-Xyl-(1->3)-β-FucNAc-β-Ser), which has not yet been reported. The presence of Pse and its β-linkage to xylose makes this synthesis very challenging. 4 Synthesize a glycopeptide containing alpha-5NβOHC4-7NFmPse-(2->4)-β-Xyl-(1->3)-β-FucNAc-β-Ser, which will lay the groundwork for synthesizing the full-length bacterial pilin glycoprotein (1-148).