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Name Card
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Professor Tse, Hung Fat 謝鴻發

Clinical Professor
Deputy Director of Institute of Cardiovascular Science and Medicine
Professor, Chair of Cardiovascular Medicine
William M W Mong Professorship in Cardiology

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
N_HKU 722/05Hypoxia-mediated differentiation of murine and human embryonic stem cells into cardiomyocytes: mechanistic roles of calcium and ion channels7960002005/2006
HKU 780110MAutologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy16000002010/2011
HKU 779512MTherapeutic Effects and Mechanism of Sympathorenal Axis Modulation by Catheter-based Renal Denervation in Porcine Model of Ischemic Heart Failure13482502012/2013
HKU 781111MAttenuation of Left Ventricular Remodeling and Improvement of Myocardial Function with Spinal Cord Stimulation in Post-myocardial Infarction Heart Failure10100002011/2012
ITS/303/12Viral-Vector Integration-Free Human Induced Pluripotent Stem Cells Platform Derived from Urine Samples for Disease Diagnosis and Drug Screening9930312012/2013
HKU 7357/02MNeovascularization of ischemic myocardium by autologous bone marrow cells transplantation8160002002/2003
HKU 7459/04MFunctional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine10512802004/2005
HKU 7594/05MEmbryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling6989572005/2006
N_HKU 730/12Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells10276192012/2013
HKU 7633/06MGenetic enrichment of cardiac derivatives from human embryonic stem cells and their bioengineering for cell-based heart therapies11545002006/2007
203217Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease14000002003/2004
HKU 776908MTransplantation of Bioengineered Human Embryonic Stem Cell-derived Cardiomyocytes with Mature Electrical Phenotype in Post-infarction Heart Failure Improves Cardiac Function Without Proarrhythmia11295162008/2009
208207Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure19650002008/2009
HKU 8/CRF/09Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases67000002009/2010
T12-705/11Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform337050002011/2012
HKU 780013MEffects of Catheter-based Splanchnic Denervation on Blood Pressure Control and Left Ventricular Remodeling in Porcine Model of Hypertensive Cardiomyopathy10392392013/2014
17121014Lower Thoracic Spinal Cord Stimulation for Treatment of Heart Failure with Preserved Ejection Fraction: Insight from a Porcine Model of Hypertensive Cardiomyopathy8658902014/2015
ITS/087/14Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management13999932014/2015
10111531Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention9990002012/2013
-Discovery of New Approaches for Treating Hyperlipidemia Using an Induced Pluripotent Stem Cell (iPSC)-Based Platform10000002015/2016
AR160106Sudden Unexpected Death (SUD) in Hong Kong12480002016/2017
StatusProject CodeProject TitleAmountFunding Year
17120715Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis5547002015/2016
ITS/150/12Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application9482322012/2013
HKU 776912MHuman Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia9500002012/2013
HKU 778212MExploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies9800002012/2013
HKU 770108MCalcium Signals and Cell Proliferation in Human Cardiac Fibroblasts13969042008/2009
HKU 777910MDriven Maturation of Embryonic Stem Cell-Derived Cardiomyocytes via Cardiac Hypertrophic Signals12000002010/2011
HKU 785611MMechanism and Reversibility of Myocardial Fibrosis in Patients with Diabetic Cardiomyopathy: Role of Aliskiren.9500002011/2012
HKU 7555/06MA prospective randomized trial of endovascular stent graft repair versus best medical treatment for patients with acute Type B aortic dissection13359062006/2007
HKU 782610MMRI Investigation of Left Ventricular Structure and Function12000002010/2011
HKU 775812MPharmacological induction of leukotriene B4 12-hydroxydehydrogenase (LTB4DH) for the resolution of neutrophil-induced myocardial injury11646052012/2013
HKU 768411MEffects of chronic periodontitis on endothelial progenitor cells: Molecular mechanisms and clinical implications7900002011/2012
HKU 763312MDoes an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?11588942012/2013
HKU 762607MDo biomarkers of inflammation and obesity predict the development of hypertension in Hong Kong Chinese?9000392007/2008
HKU 777707MPrevalence and clinical implications of exercise-induced left ventricular dyssynchrony detected by echocardiography in patients with coronary artery disease7008962007/2008
InP/079/13Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application1696432013/2014
HKU 7347/03MIonic channels of mesenchymal stem cells from bone marrow and cell proliferation6240002003/2004
InP/027/13Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application2200102012/2013
HKU 774708MLong-term Efficacy and Safety of a Gene-based Bio-artificial Pacemaker tested in a large animal Sick Sinus Syndrome Model15525642008/2009
HKU 469/96MElectromechanical remodelling of chronically fibrillating atrium after transvenous atrial defibrillation6920001996/1997
HKU 7307/00MStudy of the mechanisms of vascular homeostasis in obstructive sleep apnoea6960002000/2001
HKU 7325/00MRole of nitric oxide synthase and cyclooxygenase2 in angiogenesis after acute myocardial infarction - therapeutic implication by L-arginine8004002000/2001
HKU 7338/01MVolume-sensitive chloride current and cell volume regulation in human atrial myocytes7340002001/2002
ITS/109/02Development of multi-feature physiological signal classifier and detector for medical diagnoses38595002002/2003
GHP/027/05Development of a Suspension Antibody Array-based Multiplex Immunoassay for Early Diagnosis and Therapeutic Monitoring of Diabetes and Cardiovascular Diseases28990452005/2006
HKU 7490/06MGenomic and proteomic basis of endothelial dysfunction in regenerated endothelium9545002006/2007
HKU 7582/06MEndothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products12765502006/2007
HKU 779407MThalassaemia major: a new MRI method for detection and monitoring of heart and liver iron deposition11040182007/2008
HKU 2/07CVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention55000002007/2008
HKU 777208MCauses of Dysfunction in Regenerated Endothelium9966212008/2009
HKU 777508MAtrial Mechanical Dyssynchrony and Function in Sinus Node Disease Patients With And Without Atrial Fibrillation: Impacts of Different Modes of Atrial and Ventricular Pacing5989172008/2009
06070951A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer7716002007/2008
N_HKU 716/09Generation of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering7440002009/2010
HKU8/CRF/10Self-Assembled Synthetic Ion Channels: Design, Characterization and Biomedical Applications36000002010/2011
HKU 777713MCardiac fibroblasts derived Human induced pluripotent cells for cardiac regeneration7361282013/2014
HKU 780613MHERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis9526362013/2014
HKU 775613MNovel Therapeutic Approach for X-linked related Danon Disease  Insight from Patient-specific Pluripotent Stem Cells Platform.9526362013/2014
HKU 785013MRelationship between matrix G1a protein and osteogenic endothelial progenitor cells with vascular and valvular calcification in patients with rheumatoid arthritis: Potential therapeutic role of vitamin K6495242013/2014
01121616Mutational spectrum for dilated cardiomyopathy in Hong Kong9172702013/2014
02133066Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease9402972014/2015
C7018-14EMicro-PET for pre-clinical molecular imaging research in Hong Kong40000002014/2015
2151205Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management2707502015/2016
2151207Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk6940802015/2016
2151206Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease4800002015/2016
03143726Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies12000002015/2016
03143996Reversibility of liver stiffness after tricuspid annulopasty: A case-control study9642162015/2016
04152186Prospective evaluation of the impact of Drug-Coated Balloon in the management of true coronary bifurcation disease11215202016/2017
17120517Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing9282002017/2018
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