Name Card
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Professor Chen, Zhiwei 陳志偉

Title:
Professor, Chair of Immunology and Immunotherapy
Professor

Department:
Department of Microbiology

Faculty:
Li Ka Shing Faculty of Medicine

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
ITS/170/17A Novel Therapeutic AAV-vectored Bi-Specific Neutralizing Antibody against HIV/AIDS13995502017
 
17122915Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression9774572015
 
17115818Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection9719832018
 
C7156-20GMechanism of immune control against COVID-1989795782020
 
HKU 762811MA promising mucosal prime and intramuscular boost AIDS vaccine regimen9500002011
 
GHX/013/11SZTo Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System10019302013
 
HKU 762712MMechanism of a soluble PD-1-based vaccine in amplifying antiviral CD8+ T-cell immunity12482502012
 
17119723Role of HIV-1-specific antibodies cloned from Δ42PD-1 positive memory B cells 15769602023
 
3 R01 DA020419-02S1Cannabinoid Effects on HIV/AIDS6610652007
 
N/AUnderstanding the Ongoing HIV Epidemic in Yunnan China1950002007
 
5 R01 HL080211-03A novel model for the study of lung pathogenesis of SARS9021172007
 
HKU 762208MMucosal Vaccine against HIV-1 Infection5171972008
 
HKU 762209MRole of the PD-1/PD-L pathway in HIV-1 vaccine design9447002009
 
52117Preventing HIV-1 infection using a novel vaccine immunogen7800002008
 
09080772Characterization of novel anti-HIV/TB natural product analogues8000002009
 
N/AA Novel Vaccine for Mesothelioma Immunotherapy and Prevention;17189192010
 
MSS 183 REstablishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system15733962010
 
N_HKU 709/11Blocking HIV infection by gene-encoding neutralizing antibodies8922902011
 
11101022A Novel Vaccine for Tuberculosis Prevention9945632011
 
12110952Novel Secretory Immunoadhesins for HIV Prevention9947962012
 
InP/291/13To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System2389932013
 
13121272Further optimization of live viral vector for HIV vaccine research9471202013
 
HKU5/CRF/13GMechanism of potentiating HIV antigen-specific CD8+ T cells79843802013
 
17103514Role of a newly identified PD-1 isoform in modulating immune responses11440502014
 
ITS/194/13A New Therapeutic Vaccine for HIV/AIDS13914082014
 
17121420Combined BiIA-SG and anti-TRABD2A antibody for HIV-1 Functional Cure11955022020
 
17123422Novel mechanism restoring HBsAg-specific B cell response during chronic hepatitis B virus infection11654662022
 
14130582Role of Δ42PD1 in HIV Infection9999802014
 
A-HKU709/14A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers25501142014
 
InP/038/15A New Therapeutic Vaccine for HIV/AIDS2067482014
 
AR200035PD1-COVID19-RBD vaccine project40000002019
 
19180672Optimisation of adeno-associated viral vectors for prolonged in vivo expression of a highly potent bi-specific neutralising antibody against HIV14998322019
 
AR150049Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention13610902014
 
C1134-20GA novel vaccination strategy: using a microrobot platform for DNA vaccine delivery and antigen presentation5000002020
 
InP/034/20A Novel PD1-based Vaccine for HIV/AIDS Immunotherapy1329772020
 
AR180027Enhancing immunotherapeutic efficacy of mesothelioma by overcoming MDSC-mediated immunosuppression14143302018
 
16150442Novel human neutralizing antibodies against HIV/AIDS11998562016
 
C4045-18WDeciphering Enhancer Regulation of Tumor Immune Evasion to Develop New Combination Immunotherapies12000002018
 
AR160102Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention14999802016
 
T11-706/18-NPotentiating Host Immunity for HIV-1 Functional Cure311330002018
 
18170762HIV-1 mucosal prevention and immunotherapy by engineered tandem bi-specific IgA14999402018
 
17104919Mechanism of a Δ42PD-1-specific humanized antibody huCH101 in treating HIV/AIDS11159932019
 
17117422Mechanism of vaccine-induced mucosal immune responses against SARS-CoV-2 infection11790382022
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
T11-709/21-NEcology, molecular virology and pathogenesis of SARSCoV-2: From bedside to bench and back311360002021
 
81573373Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier6280002015
 
C7021-21G3D/4D Bioprinting liver cancer immune microenvironment for precision oncology15000002021
 
C7042-21GOrganoid-based investigations of COVID-19: Assess infectivity of mutant viruses, Evaluate vaccine efficacy and Explore disease pathogenesis65710802021
 
COVID1903010Preparing for COVID-19 upcoming challenges by clinical and virological investigations335233652021
 
13121312Role of human cytomegalovirus-triggered immune response in graft injury after living donor liver transplantation9998602013
 
03142666Role of Δ42PD1/TLR4 interaction in human hepatocellular carcinoma and its blockade as a novel immunotherapy strategy11946082015
 
17123422Novel mechanism restoring HBsAg-specific B cell response during chronic hepatitis B virus infection11654662022
 
13120612Transfer of HIV-1 from HIV-1 latently infected CD34+ hematopoietic progenitors to CD4+ T cells9801202013
 
19180632Δ42PD1 regulate metabolic alterations to compromise the B cell immunity in HIV-infected viremic individuals15000002019
 
16150662Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation11960642016
 
COVID190123Clinical study of flu-based and PD1-based vaccines for the SARS-CoV2203379342019
 
17114114Defining the role of monocyte-derived dendritic cells in potentiating durable and protective T-cell immunity by a newly identified PD-1 isoform10549622014
 
19181012The role of newly defined blood dendritic cells on HIV infection14992442019
 
11100752The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-19736322011
 
T12-703/19-RFighting Disease Recurrence and Promoting Tissue Repair after Liver Transplantation: Translating Basic Discoveries to Clinical Excellence371090002019
 
17160762Immune control of SHIV infection in rhesus macaques by PD-1 based vaccine11995482017
 
04151266Combination of dendritic cell-based vaccination and immune checkpoint blockade for malignant mesothelioma immunotherapy11808562016
 
19180642The role of transforming growth factor-beta (TGF-β) on human immunodeficiency virus (HIV) infection and latency14554122019
 
13121332Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection9979922013
 
12111162Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells9992082012
 
C7038-14GInvestigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma34870912014
 
14130742A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies9857602014
 
20190432Characterisation of pathogenetic mechanisms of Epstein-Barr virus-associated T and natural killer cell lymphoproliferative diseases in children10000002020
 
12111262Type of cell death and related mechanisms for gut homing CD4 T cells during human immunodeficiency virus-1 (HIV-1) infection9544662012
 
18171302Role of Δ42PD-1 in memory B cells exhaustion in HIV-infected viremic individuals14999362018
 
05162326Augmenting antitumor T responses of viral cancer therapy by targeting myeloid-derived suppressor cells with an armed recombinant vaccinia virus11850482017
 
T12-703/22-RCharacterization of tumor microenvironment in nasopharyngeal carcinoma77003332022
 
AR220025Preclinical Study of PD1-based TWIST1 Vaccination Approach-Promoting its Translation into Clinical Use19855202022
 
22211022Investigation on inducible factors of mitochondrial dysfunction in T cells of COVID-19 patient14823442022
 
22210852Surveillance of humoral and cellular immunity against COVID-19 among older adults with comorbidities in Hong Kong14944122022
 
T12-703/23-NInvestigation of the immunosuppressive microenvironment in nasopharyngeal carcinoma 499830002023
 
17100323Mechanism of ‘cold’ tumor elimination by in situ vaccination using engineered viral vectors13474642023