Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Professor Guan, Xin-Yuan (Project coordinator)
cancer microenvironment, FGFR2, cancer-associated fibroblast, immune surveillance, esophageal cancer
RGC Collaborative Research Fund (CRF)
HKU Project Code
Collaborative Research Fund (CRF) - Group Research Project
1) To characterize FGFR2+ cancer-associated fibroblasts (CAFs) in ESCC; 2) To investigate the effect of FGFR2+ CAFs on ESCC stemness; 3) To study the role of d42PD1/TLR4 pathway in modulating host immune surveillance.