Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma


Grant Data
Project Title
Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Principal Investigator
Professor Guan, Xin-Yuan   (Project coordinator)
Co-Investigator(s)
Dr Ma Stephanie Kwai Yee   (Co-principal investigator)
Dr Fu Grace Li   (Co-principal investigator)
Professor Chen Zhiwei   (Co-principal investigator)
Duration
36
Start Date
2015-04-01
Completion Date
2018-03-31
Amount
3487091
Conference Title
Presentation Title
Keywords
cancer microenvironment, FGFR2, cancer-associated fibroblast, immune surveillance, esophageal cancer
Discipline
Cancer,Cell Biology
Panel
Medicine
Sponsor
RGC Collaborative Research Fund (CRF)
HKU Project Code
C7038-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014/2015
Status
On-going
Objectives
1) To characterize FGFR2+ cancer-associated fibroblasts (CAFs) in ESCC; 2) To investigate the effect of FGFR2+ CAFs on ESCC stemness; 3) To study the role of d42PD1/TLR4 pathway in modulating host immune surveillance.