Delineation of reactive oxygen species (ROS)-mediated signaling pathways involved in developing chemoresistance in ovarian cancer

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Grant Data
Project Title
Delineation of reactive oxygen species (ROS)-mediated signaling pathways involved in developing chemoresistance in ovarian cancer
Principal Investigator
Dr Chan, Karen Kar Loen   (Principal Investigator (PI))
Co-Investigator(s)
Dr Chan David Wai   (Co-Investigator)
Duration
36
Start Date
2022-01-01
Amount
1365184
Conference Title
Delineation of reactive oxygen species (ROS)-mediated signaling pathways involved in developing chemoresistance in ovarian cancer
Presentation Title
Keywords
3D culture system, CSCs, NOTCH signaling, ovarian cancer, platinum-resistance, ROS
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
18191641
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2020
Status
On-going
Objectives
This study aims to delineate the regulatory mechanisms of ROS maintenance and the role of ROS in regulating NOTCH1/HES1 and JAK2/STAT5 signalings involved in CSCs formation in the 3D organoid model. Importantly, the verification of the mechanisms by clinical relevance using the recurrent and chemoresistant malignant ascites could assist in repurposing FDA-approved drugs in anti-chemoresistance in ovarian cancer.