Investigation of the effect of berberine to overcome sorafenib resistance in human hepatocellular carcinoma via suppressing Warburg effect
Grant Data
Project Title
Investigation of the effect of berberine to overcome sorafenib resistance in human hepatocellular carcinoma via suppressing Warburg effect
Principal Investigator
Dr Wang, Ning
(Principal Investigator (PI))
Co-Investigator(s)
Dr Lee Kin-Wah
(Co-Investigator)
Professor Feng Yibin
(Co-Investigator)
Duration
36
Start Date
2021-12-01
Amount
1125732
Conference Title
Investigation of the effect of berberine to overcome sorafenib resistance in human hepatocellular carcinoma via suppressing Warburg effect
Presentation Title
Keywords
Berberine, glycolysis, hepatocellular carcinoma, sorafenib resistance, Warburg effect
Discipline
Traditional Chinese Medicine (basic),Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17119621
Grant Type
General Research Fund (GRF)
Funding Year
2021
Status
On-going
Objectives
1 To comprehensively investigate the effects of berberine in overcoming in vitro and in vivo resistance of HCC cells to sorafenib 2 To determine the role of glycolysis inhibition in mediating the effect of berberine on sorafenib resistance in HCC 3 To elucidate the upstream signal and downstream response of glycolysis inhibition by berberine in sorafenib-resistant HCC