Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target.
Grant Data
Project Title
Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target.
Principal Investigator
Professor Khoo, Ui Soon
(Principal Investigator (PI))
Co-Investigator(s)
Dr Tsoi Ho
(Co-Investigator)
Dr Gong Chun
(Co-Investigator)
Duration
24
Start Date
2017-05-01
Amount
1174577
Conference Title
Hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) regulating apoptosis resistance, autophagy and cellular senescence in breast cancer: a novel potential anti-cancer target.
Presentation Title
Keywords
apoptosis resistance, autophagy, breast cancer, cellular senescence, HCN channels, HCN3
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
04151826
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
Objectives: To establish the role of HCN3 in breast cancer and the mechanism through which HCN3 confers apoptosis, autophagy and senescence resistance. Hypothesis: HCN3 helps breast cancer cells escape apoptosis through allowing the influx of potassium to restore high intracellular potassium and membrane potential.