Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.
Grant Data
Project Title
Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.
Principal Investigator
Professor Ng, Ernest Hung Yu
(Principal Investigator (PI))
Co-Investigator(s)
Dr Chan Rachel Wah Shan
(Co-Investigator)
Dr Pang Ting Kai Ronald
(Co-Investigator)
Professor Yeung William Shu Biu
(Co-Investigator)
Duration
42
Start Date
2017-01-01
Amount
1046320
Conference Title
Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation.
Presentation Title
Keywords
Endometrial Stem Cells, Menstrual Phase, Stem Cell Niche, Wnt signaling
Discipline
Reproduction,Regenerative Medicine
Panel
Biology and Medicine (M)
HKU Project Code
17158316
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To characterize the endometrial niche (epithelial and stromal) cells activated CD140b+CD146+ cells. 2 To determine the role of WNT signaling in the endometrial niche cells-induced increase in clonogenicity and proportion of CD140b+CD146+ cells. 3 To study the study the role of WNT receptors in mediating the stimulatory action of endometrial niche cells on clonogenicity and proportion of CD140b+CD146+ cells.