Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma

Emeritus Professor Lung, Maria Li   (Project Coordinator (PC))

Dr Chan Kwok Wah   (Co-principal investigator)

Dr Song You-qiang   (Co-principal investigator)

Dr Yau Stephen   (Co-principal investigator)

Professor Law Simon Ying Kit   (Co-principal investigator)

Professor Wang Li Dong   (Co-principal investigator)

Professor Lam Alfred King-yin   (Co-principal investigator)

Professor Qi Robert Zhong   (Co-principal investigator)

42

2016-06-01

7570304

Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma

biomarkers, esophageal carcinoma, genome editing, orthotopic animal model, targeted genomics

Cancer,Genomic Biology

C7031-15G

Collaborative Research Fund (CRF) - Group Research Project

2015

Completed

1. To identify cancer predisposition genes (CPGs) utilizing a targeted gene sequence capture approach and to validate the importance of shortlisted candidates in the FA-BRCA pathway for DNA damage and epigenetic remodeling pathway including BRCA2 and KMT2D, and others in larger cohorts associated with familial and sporadic Chinese ESCC in high- and moderate-risk regions; 2. To elucidate the genetic basis for ESCC utilizing genome editing and functional studies on the role of shortlisted candidate CPGs such as KMT2D, BRCA2, and others in ESCC tumorigenesis; 3. To identify and evaluate the clinical utility of shortlisted candidate CPG genes for early diagnosis of ESCC and candidates such as KMT2D or others as prognostic biomarkers for late stage ESCC and survival.