Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma


Grant Data
Project Title
Targeted Genomics and Functional Studies of Novel Cancer Predisposing Genes for Esophageal Squamous Cell Carcinoma
Principal Investigator
Professor Lung, Maria Li   (Project coordinator)
Co-Investigator(s)
Dr Yau Stephen   (Co-principal investigator)
Professor Wang Li Dong   (Co-principal investigator)
Dr Song You-qiang   (Co-principal investigator)
Professor Qi Robert Zhong   (Co-principal investigator)
Professor Law Simon Ying Kit   (Co-principal investigator)
Professor Lam Alfred King-yin   (Co-principal investigator)
Dr Chan Kwok Wah   (Co-principal investigator)
Duration
36
Start Date
2016-06-01
Completion Date
2019-05-31
Amount
7570304
Conference Title
Presentation Title
Keywords
esophageal carcinoma, targeted genomics, genome editing, biomarkers, orthotopic animal model
Discipline
Cancer,Genomic Biology
Panel
Medicine
Sponsor
RGC Collaborative Research Fund (CRF)
HKU Project Code
C7031-15G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2015/2016
Status
On-going
Objectives
1. To identify cancer predisposition genes (CPGs) utilizing a targeted gene sequence capture approach and to validate the importance of shortlisted candidates in the FA-BRCA pathway for DNA damage and epigenetic remodeling pathway including BRCA2 and KMT2D, and others in larger cohorts associated with familial and sporadic Chinese ESCC in high- and moderate-risk regions; 2. To elucidate the genetic basis for ESCC utilizing genome editing and functional studies on the role of shortlisted candidate CPGs such as KMT2D, BRCA2, and others in ESCC tumorigenesis; 3. To identify and evaluate the clinical utility of shortlisted candidate CPG genes for early diagnosis of ESCC and candidates such as KMT2D or others as prognostic biomarkers for late stage ESCC and survival.