Neurodevelopmental effect of gene-environment interaction among early-onset schizophrenia patients: a combined genetic and neuroimaging approach
Grant Data
Project Title
Neurodevelopmental effect of gene-environment interaction among early-onset schizophrenia patients: a combined genetic and neuroimaging approach
Principal Investigator
Professor Chen, Eric Yu Hai
(Principal Investigator (PI))
Co-Investigator(s)
Dr Chan Kit Wa
(Co-Investigator)
Dr Chang Wing Chung
(Co-Investigator)
Dr Tao Haojuan
(Co-Investigator)
Dr Hui Christy Lai Ming
(Co-Investigator)
Dr Zhou Li
(Co-Investigator)
Professor Liu Zhening
(Co-principal investigator)
Dr Liu Haihong
(Co-Investigator)
Dr Lin Jingxia Jessie
(Co-Investigator)
Dr Huang Xiaojun
(Co-Investigator)
Dr Deng Mengjie
(Co-Investigator)
Dr Mwansisya Tumbwene
(Co-Investigator)
Dr Lee Ho Ming Edwin
(Co-Investigator)
Duration
48
Start Date
2016-01-01
Amount
1195955
Conference Title
Neurodevelopmental effect of gene-environment interaction among early-onset schizophrenia patients: a combined genetic and neuroimaging approach
Presentation Title
Keywords
early-onset schizophrenia, Gene-environment interaction, genetic, neuroimaging
Discipline
Neuroscience,Genomic Biology
HKU Project Code
N_HKU732/15
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2015
Status
Completed
Objectives
1. To determine the expression of the dysbindin-1 isoforms and its variants in the DTNBP1 gene in the peripheral blood of Chinese early-onset schizophrenia patients and their healthy siblings. 2. To investigate the relationship between dysbindin-1 isoforms and abnormal brain structures and disconnectivity in Chinese early-onset schizophrenia patients. 3. To examine the relationship between genetic expression of dysbindin-1 isoforms and childhood trauma in the Chinese early-onset schizophrenia patients and their healthy siblings.