Exploring the mechanisms of self-referential gaze perception and its potential as an endophenotype in patients with schizophrenia-spectrum disorder


Grant Data
Project Title
Exploring the mechanisms of self-referential gaze perception and its potential as an endophenotype in patients with schizophrenia-spectrum disorder
Principal Investigator
Dr Chan, Kit Wa   (Principal investigator)
Co-Investigator(s)
Dr Chang Wing Chung   (Co-Investigator)
Dr Hui Christy Lai Ming   (Co-Investigator)
Professor Chen Eric Yu Hai   (Co-Investigator)
Dr Mak Henry Ka Fung   (Co-Investigator)
Dr Lee Ho Ming Edwin   (Co-Investigator)
Dr Cheung Charlton   (Co-Investigator)
Dr Hsiao Janet Hui Wen   (Co-Investigator)
Duration
36
Start Date
2016-01-01
Completion Date
2018-12-31
Amount
800791
Conference Title
Presentation Title
Keywords
schizophrenia, self-referential gaze
Discipline
Behaviour and Psychology
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
17112615
Grant Type
General Research Fund (GRF)
Funding Year
2015/2016
Status
On-going
Objectives
2 To investigate the potential of self-referential gaze perception (SRGP) as an endophenotype of schizophrenia-spectrum disorder: a. To establish the state-independent nature of the SRGP by studying its longitudinal changes in association with the psychopathology of patients with FEP and subjects with ARMS. b. To test the hypothesis that SRGP abnormality is present at a higher rate in non-affected siblings of patients than in healthy controls. 2 3 To investigate the potential of SRGP as a neurobiological endophenotype of schizophrenia-spectrum disorder by evaluating the neurobiological network associated with self-referential gaze perception using fMRI.