Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance


Grant Data
Project Title
Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Principal Investigator
Professor Xu, Aimin   (Principal investigator)
Co-Investigator(s)
Dr Hu Fang   (Co-Investigator)
Professor Lam Karen Siu Ling   (Co-Investigator)
Professor Zhou Zhiguang   (Co-principal investigator)
Duration
48
Start Date
2015-01-01
Completion Date
2018-12-31
Amount
1098911
Conference Title
Presentation Title
Keywords
Islet inflammation, β-cell autoimmunity, metabolic regulation, macrophages, diabetes
Discipline
Diabetes/Metabolism,Endocrinology
Panel
Medicine
Sponsor
NSFC/RGC Joint Research Scheme
HKU Project Code
N_HKU726/14
Grant Type
NSFC/RGC Joint Research Scheme
Funding Year
2014/2015
Status
On-going
Objectives
1) To investigate whether genetic ablation or pharmacological inhibition of FABP4 prevents or delay autoimmune destruction of pancreatic β cells, insulitis and overt diabetes in mice; 2) To evaluate the contribution of FABP4 to dynamic changes on infiltration and composition of immune cells in NOD mice; 3) To elucidate the molecular mechanisms by which FABP4 triggers insulitis and pancreatic β cell destruction by mediating immune cell crosstalk; 4) To explore the clinical relevance of FABP4 in the development of autoimmune diabetes in both Chinese and Caucasians.