Novel Structure and Function of Human Sirtuins


Grant Data
Project Title
Novel Structure and Function of Human Sirtuins
Principal Investigator
Professor Hao, Quan   (Project coordinator)
Co-Investigator(s)
Professor Huang Jiandong   (Co-principal investigator)
Dr Li Xiang David   (Co-principal investigator)
Duration
36
Start Date
2015-03-01
Completion Date
2018-02-28
Amount
5400000
Conference Title
Presentation Title
Keywords
crystal structure, enzymatic function, sirtuin, epigenetics, inhibitor design
Discipline
Structural Biology,Biochemistry
Panel
Medicine
Sponsor
RGC Collaborative Research Fund (CRF)
HKU Project Code
C7037-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014/2015
Status
On-going
Objectives
enzymatic functions in vitro and in vivo. 2) To probe SIRT1-3’s defatty acyl modification activity and structural basis. 3) To develop mechanism-based inhibitors for all human sirtuins (SIRT1-7).