Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma

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Grant Data
Project Title
Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Principal Investigator
Dr Chan, Kwok Wah   (Principal Investigator (PI))
Co-Investigator(s)
Dr Ma Stephanie Kwai Yee   (Co-Investigator)
Professor Law Simon Ying Kit   (Co-Investigator)
Duration
36
Start Date
2013-11-01
Amount
866032
Conference Title
Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Presentation Title
Keywords
cancer stem cell, esophagus, neuropilin-2, squamous cell carcinoma, tumour metastasis
Discipline
Cancer,Gastroenterology/Hepatobiliary
Panel
Biology and Medicine (M)
HKU Project Code
HKU 761713M
Grant Type
General Research Fund (GRF)
Funding Year
2013
Status
Completed
Objectives
1) Functional characterization of the potential pro-metastatic effect of NRP2 in ESCC; 2) Examination and delineation of NRP2 expression in CD90+ esophageal CSC subset and its role in promoting esophageal stem-like cell tumor maintenance, growth and metastasis; 3) Evaluation of the clinicopathological relevance and prognostic significance of NRP2, alone and in combination with CD90, in human ESCC samples.