Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma


Grant Data
Project Title
Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Principal Investigator
Dr Chan, Kwok Wah   (Principal investigator)
Co-Investigator(s)
Dr Ma Stephanie Kwai Yee   (Co-Investigator)
Professor Law Simon Ying Kit   (Co-Investigator)
Duration
36
Start Date
2013-11-01
Completion Date
2016-10-31
Amount
866032
Conference Title
Presentation Title
Keywords
squamous cell carcinoma, esophagus, neuropilin-2, tumour metastasis, cancer stem cell
Discipline
Cancer,Gastroenterology/Hepatobiliary
Panel
Biology and Medicine (M)
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 761713M
Grant Type
General Research Fund (GRF)
Funding Year
2013/2014
Status
On-going
Objectives
1) Functional characterization of the potential pro-metastatic effect of NRP2 in ESCC; 2) Examination and delineation of NRP2 expression in CD90+ esophageal CSC subset and its role in promoting esophageal stem-like cell tumor maintenance, growth and metastasis; 3) Evaluation of the clinicopathological relevance and prognostic significance of NRP2, alone and in combination with CD90, in human ESCC samples.