Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Dr Chan, Kwok Wah (Principal investigator)
squamous cell carcinoma, esophagus, neuropilin-2, tumour metastasis, cancer stem cell
Biology and Medicine (M)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
1) Functional characterization of the potential pro-metastatic effect of NRP2 in ESCC; 2) Examination and delineation of NRP2 expression in CD90+ esophageal CSC subset and its role in promoting esophageal stem-like cell tumor maintenance, growth and metastasis; 3) Evaluation of the clinicopathological relevance and prognostic significance of NRP2, alone and in combination with CD90, in human ESCC samples.