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Conference Paper: Detection of radiation-induced brain injuries by multi-modal magnetic resonance imaging

TitleDetection of radiation-induced brain injuries by multi-modal magnetic resonance imaging
Authors
Chan, KCCheung, MMCai, KXLau, HFTam, CNWang, SLKhong, PLWu, EX
Issue Date2008
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, ON., Canada, 3-9 May 2008. In Conference Proceedings, 2008, p. 3523 How to Cite?
AbstractThis study aimed to employ in vivo multi-modal MR imaging to understand the radiation-induced brain damage in rats in correlation to histopathological changes at 12 months after radiation treatment. Results showed a loss in contrast in the ipsilateral corpus callosum and external capsule in T2WI, with a corresponding hyperintensity in trace map. The fractional anisotropy has also dropped in the fimbria of the hippocampus, suggestive of degeneration in this white matter structure; Significant increase in Cho:Cr and Lac:Cr ratios, and a marginally significant elevation in Glu:Cr ratio were observed at the site of radiation, whereas colocalization was found between manganese-enhanced MRI pattern and immunostaining for GFAP, MnSOD and GS, likely due to their Mn-dependent upregulation against oxidative stress and glutamate excitotoxicity.
Persistent Identifierhttp://hdl.handle.net/10722/99803

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorCai, KXen_HK
dc.contributor.authorLau, HFen_HK
dc.contributor.authorTam, CNen_HK
dc.contributor.authorWang, SLen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:44:48Z-
dc.date.available2010-09-25T18:44:48Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 16th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM 2008), Toronto, ON., Canada, 3-9 May 2008. In Conference Proceedings, 2008, p. 3523en_HK
dc.identifier.urihttp://hdl.handle.net/10722/99803-
dc.description.abstractThis study aimed to employ in vivo multi-modal MR imaging to understand the radiation-induced brain damage in rats in correlation to histopathological changes at 12 months after radiation treatment. Results showed a loss in contrast in the ipsilateral corpus callosum and external capsule in T2WI, with a corresponding hyperintensity in trace map. The fractional anisotropy has also dropped in the fimbria of the hippocampus, suggestive of degeneration in this white matter structure; Significant increase in Cho:Cr and Lac:Cr ratios, and a marginally significant elevation in Glu:Cr ratio were observed at the site of radiation, whereas colocalization was found between manganese-enhanced MRI pattern and immunostaining for GFAP, MnSOD and GS, likely due to their Mn-dependent upregulation against oxidative stress and glutamate excitotoxicity.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofISMRM 2008 Annual Scientific Meeting & Exhibition Proceedingsen_HK
dc.titleDetection of radiation-induced brain injuries by multi-modal magnetic resonance imagingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros141574en_HK
dc.identifier.spage3523en_HK
dc.identifier.epage3523-

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