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Conference Paper: Evolution of MR DTI changes in neonatal rats after mild hypoxic-ischemic insult

TitleEvolution of MR DTI changes in neonatal rats after mild hypoxic-ischemic insult
Authors
Issue Date2008
PublisherInternational Society of Magnetic Resonance in Medicine
Citation
International Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 3388 How to Cite?
Abstract7-day-old mild hypoxic-ischemic (H-I) rats (n=12) were studied at 7T with diffusion tensor imaging (DTIs) in day 1, 3 and 7 post H-I insult. The apparent diffusion coefficient (ADC), fractional anisotropy (FA) and directional diffusivities (¦Ë// and ¦Ë¡Í) values were measured in white matter (WM) and gray matter (GM) lesion and their contralateral side. In day 1, the ADC, FA and ¦Ë// values showed significant decrease in GM lesion whilst WM lesion only showed a significant ADC increase. In day 3, the significant FA decrease and ¦Ë¡Í increase were found in GM lesion. Significant ADC and ¦Ë¡Í increase, and FA decrease were observed in the ipsilateral WM. By day 7, all DTI values were not statistically different between two hemispheres. Thus DTI is a sensitive method to study the early transient GM and WM changes after mild H-I insult by probing the microstructural changes.
Persistent Identifierhttp://hdl.handle.net/10722/99656

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorJin, CWen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorNiu, Gen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:39:07Z-
dc.date.available2010-09-25T18:39:07Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 3388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/99656-
dc.description.abstract7-day-old mild hypoxic-ischemic (H-I) rats (n=12) were studied at 7T with diffusion tensor imaging (DTIs) in day 1, 3 and 7 post H-I insult. The apparent diffusion coefficient (ADC), fractional anisotropy (FA) and directional diffusivities (¦Ë// and ¦Ë¡Í) values were measured in white matter (WM) and gray matter (GM) lesion and their contralateral side. In day 1, the ADC, FA and ¦Ë// values showed significant decrease in GM lesion whilst WM lesion only showed a significant ADC increase. In day 3, the significant FA decrease and ¦Ë¡Í increase were found in GM lesion. Significant ADC and ¦Ë¡Í increase, and FA decrease were observed in the ipsilateral WM. By day 7, all DTI values were not statistically different between two hemispheres. Thus DTI is a sensitive method to study the early transient GM and WM changes after mild H-I insult by probing the microstructural changes.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine-
dc.relation.ispartof2008 Proceedings of International Society of Magnetic Resonance in Medicineen_HK
dc.titleEvolution of MR DTI changes in neonatal rats after mild hypoxic-ischemic insulten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros141579en_HK
dc.identifier.spage3388en_HK

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