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Conference Paper: In vivo assessment of optic nerve degeneration in glaucoma rat model using diffusion tensor imaging

TitleIn vivo assessment of optic nerve degeneration in glaucoma rat model using diffusion tensor imaging
Authors
Issue Date2007
PublisherInternational Society for Magnetic Resonance in Medicine
Citation
Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 469 Abstract no. 2395 How to Cite?
AbstractGlaucoma is a chronic disease characterized by gradual visual field loss, cupping of the optic nerve head, and irreversible loss of retinal ganglion cells and axons. In this study, we hypothesized that diffusion tensor imaging can detect and characterize optic nerve (ON) degeneration in an established rat glaucoma model. Our results showed increased radial diffusivity and decreased FA over time largely caused by the decrease in ON axon density, while axial diffusivity remained unchanged. Such MRI approach is potentially valuable for assessing ON integrity in glaucoma patients and understanding the pathophysiological cascades involved in this disease.
Persistent Identifierhttp://hdl.handle.net/10722/99570

 

DC FieldValueLanguage
dc.contributor.authorHui, ESen_HK
dc.contributor.authorFu, SQen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:35:45Z-
dc.date.available2010-09-25T18:35:45Z-
dc.date.issued2007en_HK
dc.identifier.citationJoint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 469 Abstract no. 2395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/99570-
dc.description.abstractGlaucoma is a chronic disease characterized by gradual visual field loss, cupping of the optic nerve head, and irreversible loss of retinal ganglion cells and axons. In this study, we hypothesized that diffusion tensor imaging can detect and characterize optic nerve (ON) degeneration in an established rat glaucoma model. Our results showed increased radial diffusivity and decreased FA over time largely caused by the decrease in ON axon density, while axial diffusivity remained unchanged. Such MRI approach is potentially valuable for assessing ON integrity in glaucoma patients and understanding the pathophysiological cascades involved in this disease.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine-
dc.relation.ispartofJoint Annual Meeting ISMRM-ESMRMBen_HK
dc.titleIn vivo assessment of optic nerve degeneration in glaucoma rat model using diffusion tensor imagingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros134565en_HK

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