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Conference Paper: Manganese-enhanced MRI detected the gray matter lesions in the late phase of mild hypoxic-ischemic injury in neonatal rat

TitleManganese-enhanced MRI detected the gray matter lesions in the late phase of mild hypoxic-ischemic injury in neonatal rat
Authors
Issue Date2007
Citation
Annual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2007, p. 51-54 How to Cite?
AbstractThis study aims to use manganese-enhanced MRI (MEMRI) to investigate the progression and permanence of the gray matter injuries in a neonatal rat model by mild hypoxic-ischemia (H-I) insult. Histological analyses were performed using staining for Mn superoxide dismutase (Mn-SOD) and glutamine synthetase (GS), which are Mn-binding enzymes against oxidative stress and glutamate excitotoxicity in neurodegeneration, and the standard hematoxylin and eosin (H&E). The transient changes associated with gray matter injuries in T 2-weighted image (T2WI) and diffusion weighted image (DWI) in acute phase were shown to be detectable using MEMRI in late phase by systemic Mn 2+ administration, correlating with the local cell death, GS and Mn-SOD increase. Therefore, MEMRI may be a potentially useful diagnostic paradigm for detecting the gray matter injuries that are otherwise undetectable using the current MRI techniques in late phase of mild H-I injury. © 2007 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/99565
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:35:34Z-
dc.date.available2010-09-25T18:35:34Z-
dc.date.issued2007en_HK
dc.identifier.citationAnnual International Conference Of The Ieee Engineering In Medicine And Biology - Proceedings, 2007, p. 51-54en_HK
dc.identifier.issn0589-1019en_HK
dc.identifier.urihttp://hdl.handle.net/10722/99565-
dc.description.abstractThis study aims to use manganese-enhanced MRI (MEMRI) to investigate the progression and permanence of the gray matter injuries in a neonatal rat model by mild hypoxic-ischemia (H-I) insult. Histological analyses were performed using staining for Mn superoxide dismutase (Mn-SOD) and glutamine synthetase (GS), which are Mn-binding enzymes against oxidative stress and glutamate excitotoxicity in neurodegeneration, and the standard hematoxylin and eosin (H&E). The transient changes associated with gray matter injuries in T 2-weighted image (T2WI) and diffusion weighted image (DWI) in acute phase were shown to be detectable using MEMRI in late phase by systemic Mn 2+ administration, correlating with the local cell death, GS and Mn-SOD increase. Therefore, MEMRI may be a potentially useful diagnostic paradigm for detecting the gray matter injuries that are otherwise undetectable using the current MRI techniques in late phase of mild H-I injury. © 2007 IEEE.en_HK
dc.languageengen_HK
dc.relation.ispartofAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedingsen_HK
dc.titleManganese-enhanced MRI detected the gray matter lesions in the late phase of mild hypoxic-ischemic injury in neonatal raten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1109/IEMBS.2007.4352220en_HK
dc.identifier.pmid18001886-
dc.identifier.scopuseid_2-s2.0-84926232102en_HK
dc.identifier.hkuros132158en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57649217562&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage51en_HK
dc.identifier.epage54en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYang, J=10041733800en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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