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Conference Paper: White matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injury

TitleWhite matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injury
Authors
Issue Date2008
PublisherInternational Society of Magnetic Resonance in Medicine
Citation
International Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 670 How to Cite?
AbstractPurpose: This study aim to investigate the hypoxic-ischemic (HI) injury in brain hemisphere contralateral to ligation in neonatal rats with DTI. Rats with unilateral left carotid artery ligation were exposed to hypoxic environment for 1 hour (n=9) and 2 hours (n=9) to induce mild and severe HI injuries, respectively. They, together with intact controls (n=11) were longitudinally examined for changes in FA, axial and radial diffusivities. FA decrease and axial diffusivity increase were observed during the acute and subacute stage in the hemispheres contralateral to the ligation when compared to controls. The findings indicated that WM on seemingly normal contralateral hemisphere was indeed adversely affected, which may impact the long-term brain development after mild or severe HI injury.
Persistent Identifierhttp://hdl.handle.net/10722/99512

 

DC FieldValueLanguage
dc.contributor.authorLau, HFen_HK
dc.contributor.authorYang, Jen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:33:27Z-
dc.date.available2010-09-25T18:33:27Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Society of Magnetic Resonance in Medicine (ISMRM) 16th Scientific Meeting and Exhibition, Toronto, Canada, 3-9 May 2008, p. 670en_HK
dc.identifier.urihttp://hdl.handle.net/10722/99512-
dc.description.abstractPurpose: This study aim to investigate the hypoxic-ischemic (HI) injury in brain hemisphere contralateral to ligation in neonatal rats with DTI. Rats with unilateral left carotid artery ligation were exposed to hypoxic environment for 1 hour (n=9) and 2 hours (n=9) to induce mild and severe HI injuries, respectively. They, together with intact controls (n=11) were longitudinally examined for changes in FA, axial and radial diffusivities. FA decrease and axial diffusivity increase were observed during the acute and subacute stage in the hemispheres contralateral to the ligation when compared to controls. The findings indicated that WM on seemingly normal contralateral hemisphere was indeed adversely affected, which may impact the long-term brain development after mild or severe HI injury.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine-
dc.relation.ispartof2008 Proceedings of International Society of Magnetic Resonance in Medicineen_HK
dc.titleWhite matter alteration in brain hemisphere contralateral to ligation in neonatal rat model of hypoxic-ischemic injuryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros141570en_HK
dc.identifier.spage670en_HK

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