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Conference Paper: High prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients

TitleHigh prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patients
Authors
Issue Date2007
PublisherRadiological Society of North America
Citation
Radiological Society of North America (RSNA) 93rd Scientific Assembly and Annual Meeting, Chicago, IL, 25-30 November 2007 How to Cite?
AbstractPURPOSE Coronary artery (CA), aorta calcium score (CS) and carotid artery CS are greatly related to the risks of coronary heart disease (CHD) and stroke. MDCT is an accurate method to evaluate CS in CA, aorta and carotid artery. Purpose of this study is to evaluate prevalence and extent of CS in RA patients without CHD and stroke and compare with controls. METHOD AND MATERIALS During one year period, continuous 85 RA patients confirmed by diagnostic criteria were enrolled in this study (mean age 54±12, 73 female). Meanwhile, controls were selected from a database of healthy volunteers (mean age 56±10, 70 female). Clinical information and related blood test results were collected at the same period. All subjects underwent 64MDCT CS scan. CS was measured in CA, carotid artery (common and internal carotid artery) and aorta (ascending and descending aorta). Student’s t test and Fisher’s exact test were used to compare significant difference. Adjusted odds ratios were obtained from logistic regression model after controlling for age, sex and BP. RESULTS Cases and controls had matched age, sex and race. Significantly higher prevalence and extent of CS were noted in CA, aorta and carotid artery in RA group. Mean prevalence of CA, aorta and carotid artery CS in cases and controls were 34% vs 16% (p=0.01), 65% vs 12% (p<0.0001) and 19% vs 6% (p=0.02). Mean CS were 63±197 vs 11±39 (p=0.01) in CA, 168±549 vs 28±168 (p<0.0001) in aorta and 21±95 vs 7±34 (p=0.01) in carotid artery. 74% (n=63) of RA vs 26% (n=22) of controls (p<0.0001) found calcium atherosclerosis. When adjusted for age, sex and BP, RA increased 4.7, 5.4 and 19.4 risk folds to have calcium atherosclerosis in CA, carotid artery and aorta. Traditional CHD risk factors, special anti-RA drugs did no significantly affect on this status. CONCLUSION Our results demonstrated a significantly higher prevalence and extent of calcium atherosclerosis in CA, aorta and carotid artery in RA patients without CHD and stroke than controls. CLINICAL RELEVANCE/APPLICATION RA is an independent risk factor of asymptomatic atherosclerosis in CA, aorta and carotid artery.
Persistent Identifierhttp://hdl.handle.net/10722/98765

 

DC FieldValueLanguage
dc.contributor.authorWang, Sen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorOoi, CGCen_HK
dc.date.accessioned2010-09-25T18:01:23Z-
dc.date.available2010-09-25T18:01:23Z-
dc.date.issued2007en_HK
dc.identifier.citationRadiological Society of North America (RSNA) 93rd Scientific Assembly and Annual Meeting, Chicago, IL, 25-30 November 2007-
dc.identifier.urihttp://hdl.handle.net/10722/98765-
dc.description.abstractPURPOSE Coronary artery (CA), aorta calcium score (CS) and carotid artery CS are greatly related to the risks of coronary heart disease (CHD) and stroke. MDCT is an accurate method to evaluate CS in CA, aorta and carotid artery. Purpose of this study is to evaluate prevalence and extent of CS in RA patients without CHD and stroke and compare with controls. METHOD AND MATERIALS During one year period, continuous 85 RA patients confirmed by diagnostic criteria were enrolled in this study (mean age 54±12, 73 female). Meanwhile, controls were selected from a database of healthy volunteers (mean age 56±10, 70 female). Clinical information and related blood test results were collected at the same period. All subjects underwent 64MDCT CS scan. CS was measured in CA, carotid artery (common and internal carotid artery) and aorta (ascending and descending aorta). Student’s t test and Fisher’s exact test were used to compare significant difference. Adjusted odds ratios were obtained from logistic regression model after controlling for age, sex and BP. RESULTS Cases and controls had matched age, sex and race. Significantly higher prevalence and extent of CS were noted in CA, aorta and carotid artery in RA group. Mean prevalence of CA, aorta and carotid artery CS in cases and controls were 34% vs 16% (p=0.01), 65% vs 12% (p<0.0001) and 19% vs 6% (p=0.02). Mean CS were 63±197 vs 11±39 (p=0.01) in CA, 168±549 vs 28±168 (p<0.0001) in aorta and 21±95 vs 7±34 (p=0.01) in carotid artery. 74% (n=63) of RA vs 26% (n=22) of controls (p<0.0001) found calcium atherosclerosis. When adjusted for age, sex and BP, RA increased 4.7, 5.4 and 19.4 risk folds to have calcium atherosclerosis in CA, carotid artery and aorta. Traditional CHD risk factors, special anti-RA drugs did no significantly affect on this status. CONCLUSION Our results demonstrated a significantly higher prevalence and extent of calcium atherosclerosis in CA, aorta and carotid artery in RA patients without CHD and stroke than controls. CLINICAL RELEVANCE/APPLICATION RA is an independent risk factor of asymptomatic atherosclerosis in CA, aorta and carotid artery.-
dc.languageengen_HK
dc.publisherRadiological Society of North America-
dc.relation.ispartofRadiological Society of North America (RSNA) Scientific Assembly and Annual Meeting, RSNA 2007en_HK
dc.titleHigh prevalence of asymptomatic calcium atherosclerosis in rheumatoid arthritis patientsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWang, S: pkuwangsilun@yahoo.com.cnen_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailOoi, CGC: cgcooi@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.hkuros138999en_HK

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