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Conference Paper: Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model

TitleManganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model
Authors
Issue Date2007
PublisherInternational Society for Magnetic Resonance in Medicine
Citation
Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 72 Abstract no. 313 How to Cite?
AbstractThis study aims to investigate the spatial-temporal MRI changes with and without systemic MnCl2 injection in neonatal rats with severe hypoxic-ischemic (H-I) injury. Manganese-enhanced MRI (MEMRI) by intraperitoneal injection enhanced the detection of damages in cortical, hippocampus and basal ganglia regions during the middle and later phase of neonatal H-I injury. However, in acute phase, no Mn enhancement was observed in edema area despite that blood-brain-barrier is disrupted. Histopathological examinations revealed that T1-weighted Mn enhancement by exogenous Mn was associated with increased Mn-superoxide dismutase (MnSOD) production, and hypointensity in T2-weighted MRI was associated with iron and Mn accumulation.
Persistent Identifierhttp://hdl.handle.net/10722/98758

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorMa, Den_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-25T18:01:06Z-
dc.date.available2010-09-25T18:01:06Z-
dc.date.issued2007en_HK
dc.identifier.citationJoint Annual Meeting ISMRM-ESMRMB, Berlin, Germany, 19-25 May 2007. In 2007 Scientific Meeting Proceedings, 2007, p. 72 Abstract no. 313-
dc.identifier.urihttp://hdl.handle.net/10722/98758-
dc.description.abstractThis study aims to investigate the spatial-temporal MRI changes with and without systemic MnCl2 injection in neonatal rats with severe hypoxic-ischemic (H-I) injury. Manganese-enhanced MRI (MEMRI) by intraperitoneal injection enhanced the detection of damages in cortical, hippocampus and basal ganglia regions during the middle and later phase of neonatal H-I injury. However, in acute phase, no Mn enhancement was observed in edema area despite that blood-brain-barrier is disrupted. Histopathological examinations revealed that T1-weighted Mn enhancement by exogenous Mn was associated with increased Mn-superoxide dismutase (MnSOD) production, and hypointensity in T2-weighted MRI was associated with iron and Mn accumulation.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine-
dc.relation.ispartofJoint Annual Meeting ISMRM-ESMRMBen_HK
dc.titleManganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat modelen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.hkuros128816en_HK
dc.identifier.hkuros141501-

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