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Conference Paper: The utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinoma

TitleThe utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinoma
Authors
Issue Date2010
PublisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org/site/misc/JNM_Meeting_Abstracts_Info.xhtml
Citation
The 57th Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT., 5-9 June 2010. In Journal of Nuclear Medicine, 2010, v. 51 suppl. 2, abstract no. 460 How to Cite?
Abstract
OBJECTIVES: 18F-FDG PET/CT (FDG) has a limitation in assessing skull base involvement in patients with nasopharyngeal carcinoma (NPC) but this assessment is essential for radiotherapy planning. We aimed at investigating the utility of 18F-Fluoride (F18) as an adjunct to FDG in the detection of skull base involvement in these patients. METHODS: All patients referred to PET scan for staging of histologically proven NPC from 2006 to 2009 were reviewed and those with FDG, F18 PET/CT and MRI within 1 month were recruited into this study. MRI was chosen as the preliminary standard of reference in place of invasive histopathological proof. FDG and F18 PET/CT scans were reviewed by 3 nuclear medicine physicians in consensus for the presence/absence of skull base involvement, and the level of confidence (1-3) was scored for each scan. MRI scans were reviewed by 2 radiologists. Reviewers were blinded to the other imaging modality. RESULTS: A total of 20 patients (M: 15, F: 5, mean: 48y) with 16 newly diagnosed and 4 recurrent NPC were evaluated. MRI detected 15 with and 5 without skull base involvement. FDG PET/CT detected 10 and F18 PET/CT detected 11 with skull base involvement, which were all true positive. Therefore the sensitivity, specificity and accuracy of FDG alone and F18 were 67% (10/15) vs 73% (11/15); 100% (5/5) vs 100% (5/5); and 75% (15/20) vs 80% (16/20) respectively. F18 increased the level of confidence for 12 and remained the same for 3. FDG was limited by ‘blooming’ effect or down scatter by intense uptake of the tumor or brain cortex, and faint equivocal uptake in the involved marrow. Non-specific uptake under benign conditions or irradiation changes for recurrent cases might lead to false interpretation of F18. CONCLUSIONS: F18 has an adjunctive role to FDG PET/CT in increasing the detection sensitivity and confidence of skull base involvement in NPC patients
DescriptionSession: Oncology-Clinical Diagnosis: Head & Neck - Head & Neck II
Persistent Identifierhttp://hdl.handle.net/10722/98727
ISSN
2013 Impact Factor: 5.563
2013 SCImago Journal Rankings: 2.254

 

DC FieldValueLanguage
dc.contributor.authorLau, YCen_HK
dc.contributor.authorHo, CLen_HK
dc.contributor.authorLeung, YLen_HK
dc.contributor.authorCheng, Ten_HK
dc.contributor.authorYeung, WDen_HK
dc.contributor.authorAnthony, Men_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-09-25T17:59:45Z-
dc.date.available2010-09-25T17:59:45Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 57th Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT., 5-9 June 2010. In Journal of Nuclear Medicine, 2010, v. 51 suppl. 2, abstract no. 460-
dc.identifier.issn0161-5505-
dc.identifier.urihttp://hdl.handle.net/10722/98727-
dc.descriptionSession: Oncology-Clinical Diagnosis: Head & Neck - Head & Neck II-
dc.descriptionOpen Access Journal-
dc.description.abstractOBJECTIVES: 18F-FDG PET/CT (FDG) has a limitation in assessing skull base involvement in patients with nasopharyngeal carcinoma (NPC) but this assessment is essential for radiotherapy planning. We aimed at investigating the utility of 18F-Fluoride (F18) as an adjunct to FDG in the detection of skull base involvement in these patients. METHODS: All patients referred to PET scan for staging of histologically proven NPC from 2006 to 2009 were reviewed and those with FDG, F18 PET/CT and MRI within 1 month were recruited into this study. MRI was chosen as the preliminary standard of reference in place of invasive histopathological proof. FDG and F18 PET/CT scans were reviewed by 3 nuclear medicine physicians in consensus for the presence/absence of skull base involvement, and the level of confidence (1-3) was scored for each scan. MRI scans were reviewed by 2 radiologists. Reviewers were blinded to the other imaging modality. RESULTS: A total of 20 patients (M: 15, F: 5, mean: 48y) with 16 newly diagnosed and 4 recurrent NPC were evaluated. MRI detected 15 with and 5 without skull base involvement. FDG PET/CT detected 10 and F18 PET/CT detected 11 with skull base involvement, which were all true positive. Therefore the sensitivity, specificity and accuracy of FDG alone and F18 were 67% (10/15) vs 73% (11/15); 100% (5/5) vs 100% (5/5); and 75% (15/20) vs 80% (16/20) respectively. F18 increased the level of confidence for 12 and remained the same for 3. FDG was limited by ‘blooming’ effect or down scatter by intense uptake of the tumor or brain cortex, and faint equivocal uptake in the involved marrow. Non-specific uptake under benign conditions or irradiation changes for recurrent cases might lead to false interpretation of F18. CONCLUSIONS: F18 has an adjunctive role to FDG PET/CT in increasing the detection sensitivity and confidence of skull base involvement in NPC patients-
dc.languageengen_HK
dc.publisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org/site/misc/JNM_Meeting_Abstracts_Info.xhtml-
dc.relation.ispartofJournal of Nuclear Medicineen_HK
dc.titleThe utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailAnthony, M: anthonym@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hku.hken_HK
dc.identifier.authorityAnthony, M=rp01302en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros169958en_HK
dc.identifier.volume51-
dc.identifier.issuesuppl. 2-
dc.publisher.placeUnited States-

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