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Conference Paper: The utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinoma
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TitleThe utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinoma
 
AuthorsLau, YC
Ho, CL
Leung, YL
Cheng, T
Yeung, WD
Anthony, M
Khong, PL
 
Issue Date2010
 
PublisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org/site/misc/JNM_Meeting_Abstracts_Info.xhtml
 
CitationThe 57th Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT., 5-9 June 2010. In Journal of Nuclear Medicine, 2010, v. 51 suppl. 2, abstract no. 460 [How to Cite?]
 
AbstractOBJECTIVES: 18F-FDG PET/CT (FDG) has a limitation in assessing skull base involvement in patients with nasopharyngeal carcinoma (NPC) but this assessment is essential for radiotherapy planning. We aimed at investigating the utility of 18F-Fluoride (F18) as an adjunct to FDG in the detection of skull base involvement in these patients. METHODS: All patients referred to PET scan for staging of histologically proven NPC from 2006 to 2009 were reviewed and those with FDG, F18 PET/CT and MRI within 1 month were recruited into this study. MRI was chosen as the preliminary standard of reference in place of invasive histopathological proof. FDG and F18 PET/CT scans were reviewed by 3 nuclear medicine physicians in consensus for the presence/absence of skull base involvement, and the level of confidence (1-3) was scored for each scan. MRI scans were reviewed by 2 radiologists. Reviewers were blinded to the other imaging modality. RESULTS: A total of 20 patients (M: 15, F: 5, mean: 48y) with 16 newly diagnosed and 4 recurrent NPC were evaluated. MRI detected 15 with and 5 without skull base involvement. FDG PET/CT detected 10 and F18 PET/CT detected 11 with skull base involvement, which were all true positive. Therefore the sensitivity, specificity and accuracy of FDG alone and F18 were 67% (10/15) vs 73% (11/15); 100% (5/5) vs 100% (5/5); and 75% (15/20) vs 80% (16/20) respectively. F18 increased the level of confidence for 12 and remained the same for 3. FDG was limited by ‘blooming’ effect or down scatter by intense uptake of the tumor or brain cortex, and faint equivocal uptake in the involved marrow. Non-specific uptake under benign conditions or irradiation changes for recurrent cases might lead to false interpretation of F18. CONCLUSIONS: F18 has an adjunctive role to FDG PET/CT in increasing the detection sensitivity and confidence of skull base involvement in NPC patients
 
DescriptionSession: Oncology-Clinical Diagnosis: Head & Neck - Head & Neck II
Open Access Journal
 
ISSN0161-5505
2013 Impact Factor: 5.563
2013 SCImago Journal Rankings: 2.254
 
DC FieldValue
dc.contributor.authorLau, YC
 
dc.contributor.authorHo, CL
 
dc.contributor.authorLeung, YL
 
dc.contributor.authorCheng, T
 
dc.contributor.authorYeung, WD
 
dc.contributor.authorAnthony, M
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2010-09-25T17:59:45Z
 
dc.date.available2010-09-25T17:59:45Z
 
dc.date.issued2010
 
dc.description.abstractOBJECTIVES: 18F-FDG PET/CT (FDG) has a limitation in assessing skull base involvement in patients with nasopharyngeal carcinoma (NPC) but this assessment is essential for radiotherapy planning. We aimed at investigating the utility of 18F-Fluoride (F18) as an adjunct to FDG in the detection of skull base involvement in these patients. METHODS: All patients referred to PET scan for staging of histologically proven NPC from 2006 to 2009 were reviewed and those with FDG, F18 PET/CT and MRI within 1 month were recruited into this study. MRI was chosen as the preliminary standard of reference in place of invasive histopathological proof. FDG and F18 PET/CT scans were reviewed by 3 nuclear medicine physicians in consensus for the presence/absence of skull base involvement, and the level of confidence (1-3) was scored for each scan. MRI scans were reviewed by 2 radiologists. Reviewers were blinded to the other imaging modality. RESULTS: A total of 20 patients (M: 15, F: 5, mean: 48y) with 16 newly diagnosed and 4 recurrent NPC were evaluated. MRI detected 15 with and 5 without skull base involvement. FDG PET/CT detected 10 and F18 PET/CT detected 11 with skull base involvement, which were all true positive. Therefore the sensitivity, specificity and accuracy of FDG alone and F18 were 67% (10/15) vs 73% (11/15); 100% (5/5) vs 100% (5/5); and 75% (15/20) vs 80% (16/20) respectively. F18 increased the level of confidence for 12 and remained the same for 3. FDG was limited by ‘blooming’ effect or down scatter by intense uptake of the tumor or brain cortex, and faint equivocal uptake in the involved marrow. Non-specific uptake under benign conditions or irradiation changes for recurrent cases might lead to false interpretation of F18. CONCLUSIONS: F18 has an adjunctive role to FDG PET/CT in increasing the detection sensitivity and confidence of skull base involvement in NPC patients
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionSession: Oncology-Clinical Diagnosis: Head & Neck - Head & Neck II
 
dc.descriptionOpen Access Journal
 
dc.identifier.citationThe 57th Annual Meeting of the Society of Nuclear Medicine (SNM), Salt Lake City, UT., 5-9 June 2010. In Journal of Nuclear Medicine, 2010, v. 51 suppl. 2, abstract no. 460 [How to Cite?]
 
dc.identifier.hkuros169958
 
dc.identifier.issn0161-5505
2013 Impact Factor: 5.563
2013 SCImago Journal Rankings: 2.254
 
dc.identifier.issuesuppl. 2
 
dc.identifier.urihttp://hdl.handle.net/10722/98727
 
dc.identifier.volume51
 
dc.languageeng
 
dc.publisherSociety of Nuclear Medicine. The Journal's web site is located at http://jnm.snmjournals.org/site/misc/JNM_Meeting_Abstracts_Info.xhtml
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Nuclear Medicine
 
dc.titleThe utility of 18F-Fluoride PET/CT for the detection of skull base involvement in nasopharyngeal carcinoma
 
dc.typeConference_Paper
 
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<contributor.author>Ho, CL</contributor.author>
<contributor.author>Leung, YL</contributor.author>
<contributor.author>Cheng, T</contributor.author>
<contributor.author>Yeung, WD</contributor.author>
<contributor.author>Anthony, M</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<date.accessioned>2010-09-25T17:59:45Z</date.accessioned>
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<description.abstract>OBJECTIVES: 18F-FDG PET/CT (FDG) has a limitation in assessing skull base involvement in patients with nasopharyngeal carcinoma (NPC) but this assessment is essential for radiotherapy planning. We aimed at investigating the utility of 18F-Fluoride (F18) as an adjunct to FDG in the detection of skull base involvement in these patients. METHODS: All patients referred to PET scan for staging of histologically proven NPC from 2006 to 2009 were reviewed and those with FDG, F18 PET/CT and MRI within 1 month were recruited into this study. MRI was chosen as the preliminary standard of reference in place of invasive histopathological proof. FDG and F18 PET/CT scans were reviewed by 3 nuclear medicine physicians in consensus for the presence/absence of skull base involvement, and the level of confidence (1-3) was scored for each scan. MRI scans were reviewed by 2 radiologists. Reviewers were blinded to the other imaging modality. RESULTS: A total of 20 patients (M: 15, F: 5, mean: 48y) with 16 newly diagnosed and 4 recurrent NPC were evaluated. MRI detected 15 with and 5 without skull base involvement. FDG PET/CT detected 10 and F18 PET/CT detected 11 with skull base involvement, which were all true positive. Therefore the sensitivity, specificity and accuracy of FDG alone and F18 were 67% (10/15) vs 73% (11/15); 100% (5/5) vs 100% (5/5); and 75% (15/20) vs 80% (16/20) respectively. F18 increased the level of confidence for 12 and remained the same for 3. FDG was limited by &#8216;blooming&#8217; effect or down scatter by intense uptake of the tumor or brain cortex, and faint equivocal uptake in the involved marrow. Non-specific uptake under benign conditions or irradiation changes for recurrent cases might lead to false interpretation of F18. CONCLUSIONS: F18 has an adjunctive role to FDG PET/CT in increasing the detection sensitivity and confidence of skull base involvement in NPC patients</description.abstract>
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