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Conference Paper: Pilot findings of a cluster randomized trial of non-pharmaceutical interventions for influenza prevention in households in Hong Kong

TitlePilot findings of a cluster randomized trial of non-pharmaceutical interventions for influenza prevention in households in Hong Kong
Authors
Issue Date2008
PublisherCenters for Disease Control and Prevention.
Citation
The 6th International Conference on Emerging Infectious Diseases, Atlanta, GA, 16-19 March 2008, p. 31-32 How to Cite?
AbstractBackground: There are sparse data on the efficacy of non-pharmacological interventions for prevention of influenza virus transmission. We implemented a pilot study of the feasibility and efficacy of masks and hand hygiene to reduce transmission in Hong Kong households (February to September 2007) as part of a larger community trial planned for 2008. Methods: We conducted a cluster randomized controlled trial of households (composed of at least 3 members) where an index subject presented with influenza-like-illness of <48-hour duration. After confirmation as influenza by the QuickVue Influenza A+B rapid test, the household was randomized to 1) control group or 2) surgical masks or 3) hand hygiene. Households were visited within 36 hours, and again 3, 6 and 9 days later. Nose and throat swabs were collected from index subjects and household contacts at each home visit and tested by viral culture. The primary outcome measure was laboratory confirmed influenza in a household contact; secondary outcome was clinical influenza (by self-reported symptoms). Results: We randomized 198 households and completed follow up home visits in 128 households. There were 23 household contacts with laboratory confirmed influenza and 41 with clinical influenza, corresponding to secondary attack ratios of 4% and 8% respectively. The secondary attack ratios did not significantly differ across the intervention groups. In multivariable regression models, history of influenza vaccination and younger age of the corresponding index subject were associated with lower risk of secondary infection, but were not statistically significant at the 0.05 level. Conclusions: The secondary attack ratios were lower than anticipated, and lower than in previous studies in Western settings, perhaps due to differing patterns of susceptibility, lack of significant viral strain drift, and/or issues related to the symptomatic recruitment design.
Persistent Identifierhttp://hdl.handle.net/10722/97868

 

DC FieldValueLanguage
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorCheng, KYen_HK
dc.contributor.authorFung, ROPen_HK
dc.contributor.authorFang, Jen_HK
dc.contributor.authorLam, CLHen_HK
dc.contributor.authorHo, LMen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorSeto, WHen_HK
dc.contributor.authorYung, Ren_HK
dc.contributor.authorUyeki, TMen_HK
dc.contributor.authorHouck, PMen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLeung, GMen_HK
dc.date.accessioned2010-09-25T17:25:39Z-
dc.date.available2010-09-25T17:25:39Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 6th International Conference on Emerging Infectious Diseases, Atlanta, GA, 16-19 March 2008, p. 31-32en_HK
dc.identifier.urihttp://hdl.handle.net/10722/97868-
dc.description.abstractBackground: There are sparse data on the efficacy of non-pharmacological interventions for prevention of influenza virus transmission. We implemented a pilot study of the feasibility and efficacy of masks and hand hygiene to reduce transmission in Hong Kong households (February to September 2007) as part of a larger community trial planned for 2008. Methods: We conducted a cluster randomized controlled trial of households (composed of at least 3 members) where an index subject presented with influenza-like-illness of <48-hour duration. After confirmation as influenza by the QuickVue Influenza A+B rapid test, the household was randomized to 1) control group or 2) surgical masks or 3) hand hygiene. Households were visited within 36 hours, and again 3, 6 and 9 days later. Nose and throat swabs were collected from index subjects and household contacts at each home visit and tested by viral culture. The primary outcome measure was laboratory confirmed influenza in a household contact; secondary outcome was clinical influenza (by self-reported symptoms). Results: We randomized 198 households and completed follow up home visits in 128 households. There were 23 household contacts with laboratory confirmed influenza and 41 with clinical influenza, corresponding to secondary attack ratios of 4% and 8% respectively. The secondary attack ratios did not significantly differ across the intervention groups. In multivariable regression models, history of influenza vaccination and younger age of the corresponding index subject were associated with lower risk of secondary infection, but were not statistically significant at the 0.05 level. Conclusions: The secondary attack ratios were lower than anticipated, and lower than in previous studies in Western settings, perhaps due to differing patterns of susceptibility, lack of significant viral strain drift, and/or issues related to the symptomatic recruitment design.-
dc.languageengen_HK
dc.publisherCenters for Disease Control and Prevention.en_HK
dc.relation.ispartofInternational Conference on Emerging Infectious Diseases, ICEID 2008en_HK
dc.titlePilot findings of a cluster randomized trial of non-pharmaceutical interventions for influenza prevention in households in Hong Kongen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.emailFung, ROP: flustudy@hku.hken_HK
dc.identifier.emailFang, J: vickyst@hkusua.hku.hken_HK
dc.identifier.emailLam, CLH: conrad.lam@gmail.comen_HK
dc.identifier.emailHo, LM: lmho@hkucc.hku.hken_HK
dc.identifier.emailChan, KH: chankh2@HKUCC.hku.hken_HK
dc.identifier.emailSeto, WH: whseto@HKUCC.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.authorityHo, LM=rp00360en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.hkuros142754en_HK
dc.identifier.spage31en_HK

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