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Conference Paper: Modifications in perineuronal nets within the rat vestibular nuclei during postnatal development and in injury

TitleModifications in perineuronal nets within the rat vestibular nuclei during postnatal development and in injury
Authors
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006), Kyoto, Japan, 19–21 July 2006. In Neuroscience Research, 2006, v. 55 n. S1, p. S171 How to Cite?
AbstractTo determine whether perineuronal nets (PN) within the vestibular nuclei contribute to plasticity of central connectivity, we studied the presentation of PN within the vestibular nuclei during development (rats, P1 to adult) and after unilateral labyrinthectomy (UL) in the adult. Histochemistry with the lectin Wisteria floribunda agglutinin was used to map PN about NeuN-immunopositive neurons within the vestibular nuclei. In normal postnatal rats, PN was detectable by P3 in the vestibular nucleus as fuzziness about neuronal cell bodies. From P9 onwards, the fuzzy PN progressively consolidated into a network organization. The fuzziness was no longer observable after P12. During postnatal development, the number of neurons showing PN increased with age, reaching the adult level by P21. With UL, the PN network on the lesioned side remained compact until 5 days post-lesion when the fuzziness reminiscent of that in early postnatal rats became evident. By 11 days after UL, the PN of some neurons resumed the network pattern as was observed in normal adult rats. This phenomenon was found in the PN of the remaining neurons by 14 days after UL. The PN on the labyrinth-intact side showed the compact network of uninjured age-matched rats. Taken together, our findings indicate PN changes that suggest possible correlation with vestibular nuclear neuronal function both during postnatal development of normal rats as well as in adult rats following destruction of the ipsilateral inner ear.
Persistent Identifierhttp://hdl.handle.net/10722/96339
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T16:30:45Z-
dc.date.available2010-09-25T16:30:45Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006), Kyoto, Japan, 19–21 July 2006. In Neuroscience Research, 2006, v. 55 n. S1, p. S171en_HK
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/96339-
dc.description.abstractTo determine whether perineuronal nets (PN) within the vestibular nuclei contribute to plasticity of central connectivity, we studied the presentation of PN within the vestibular nuclei during development (rats, P1 to adult) and after unilateral labyrinthectomy (UL) in the adult. Histochemistry with the lectin Wisteria floribunda agglutinin was used to map PN about NeuN-immunopositive neurons within the vestibular nuclei. In normal postnatal rats, PN was detectable by P3 in the vestibular nucleus as fuzziness about neuronal cell bodies. From P9 onwards, the fuzzy PN progressively consolidated into a network organization. The fuzziness was no longer observable after P12. During postnatal development, the number of neurons showing PN increased with age, reaching the adult level by P21. With UL, the PN network on the lesioned side remained compact until 5 days post-lesion when the fuzziness reminiscent of that in early postnatal rats became evident. By 11 days after UL, the PN of some neurons resumed the network pattern as was observed in normal adult rats. This phenomenon was found in the PN of the remaining neurons by 14 days after UL. The PN on the labyrinth-intact side showed the compact network of uninjured age-matched rats. Taken together, our findings indicate PN changes that suggest possible correlation with vestibular nuclear neuronal function both during postnatal development of normal rats as well as in adult rats following destruction of the ipsilateral inner ear.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleModifications in perineuronal nets within the rat vestibular nuclei during postnatal development and in injuryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailMa, CW: h0494175@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2006.04.004-
dc.identifier.hkuros129775en_HK

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