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Conference Paper: Potential significance of polysaccharides from nerium indicum in neuroprotection

TitlePotential significance of polysaccharides from nerium indicum in neuroprotection
Authors
KeywordsNEUROPROTECTION
BETA AMYLOID
CASPASE-3
ALZHEIMER'S DISEASE
Issue Date2003
PublisherSociety for Neuroscience
Citation
Neuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 98.5 How to Cite?
AbstractPolysaccharides isolated from Traditional Chinese Medicine have long been known to have therapeutic effects on various diseases. At present, the majority of the research has been focus on their immune responses and anti-cancer properties. Little is known about the effects on neurons. Polysaccharides isolated from the flowers of Nerium indicum has been reported to have neurotrophic effect on PC12 cells, an effect similar to that of nerve growth factor. We aim to extend this line of study by examining whether these polysaccharides can provide significant effects in NEUROPROTECTION for neurons against serum-deprivation or BETA AMYLOID peptide (Aβ) toxicity. While neurons exposed to serum free medium resulted in DNA fragmentation and condensation by DAPI staining, pre-treatment of the polysaccharides significantly reduced the number of apoptotic neurons. Besides serum-deprivation, the polysaccharides could also significantly attenuated activation of CASPASE-3. Apart from their biological effects on neurons, we have also elucidated the chemical structures of these polysaccharides by various chemical techniques. The results strongly suggest that polysaccharides from N. indicum have potential clinical application as neuroprotective agent against toxic factors involved in aging and ALZHEIMER'S DISEASE.
Persistent Identifierhttp://hdl.handle.net/10722/95757

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorLin, KFen_HK
dc.contributor.authorFang, Jen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T16:12:17Z-
dc.date.available2010-09-25T16:12:17Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 98.5en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95757-
dc.description.abstractPolysaccharides isolated from Traditional Chinese Medicine have long been known to have therapeutic effects on various diseases. At present, the majority of the research has been focus on their immune responses and anti-cancer properties. Little is known about the effects on neurons. Polysaccharides isolated from the flowers of Nerium indicum has been reported to have neurotrophic effect on PC12 cells, an effect similar to that of nerve growth factor. We aim to extend this line of study by examining whether these polysaccharides can provide significant effects in NEUROPROTECTION for neurons against serum-deprivation or BETA AMYLOID peptide (Aβ) toxicity. While neurons exposed to serum free medium resulted in DNA fragmentation and condensation by DAPI staining, pre-treatment of the polysaccharides significantly reduced the number of apoptotic neurons. Besides serum-deprivation, the polysaccharides could also significantly attenuated activation of CASPASE-3. Apart from their biological effects on neurons, we have also elucidated the chemical structures of these polysaccharides by various chemical techniques. The results strongly suggest that polysaccharides from N. indicum have potential clinical application as neuroprotective agent against toxic factors involved in aging and ALZHEIMER'S DISEASE.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectNEUROPROTECTION-
dc.subjectBETA AMYLOID-
dc.subjectCASPASE-3-
dc.subjectALZHEIMER'S DISEASE-
dc.titlePotential significance of polysaccharides from nerium indicum in neuroprotectionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYu, MS: ymsmabel@graduate.hku.hken_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.hkuros85224en_HK

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