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Conference Paper: Neuroprotective effects of transplanted olfactory ensheathing cells on axotimized retinal ganglion cells in adult rats

TitleNeuroprotective effects of transplanted olfactory ensheathing cells on axotimized retinal ganglion cells in adult rats
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S90 Abstract no. P1-d37 How to Cite?
AbstractAlthough olfactory ensheathing cells (OECs) have been successfully used to enhance axon regeneration within the injured central nervous system, no evidence could demonstrate any in vivo protective effect of such macroglial cells on injured central neurons. In the present study, we investigated the effect of OECs on neuronal survival of axotomized retinal ganglion cells (RGCs) in adult rats. OECs suspension or the same volume of DMEM/F12 medium was injected into the ocular stump of the orbitally transected ON in the experimental or control group. All animals were allowed to survive for 2, 7 or 14 days, respectively, following operation and the numbers of FluoroGold-labeled RGCs were counted. A significantly higher number (P < 0.01) was detected at 7 day in the experimental group than in the control group. Thus, transplanted OECs are capable of protecting injured RGCs at a certain period after ON transection.
Persistent Identifierhttp://hdl.handle.net/10722/95689
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorWu, Men_HK
dc.contributor.authorHou, Ben_HK
dc.contributor.authorYang, Hen_HK
dc.contributor.authorLuo, Nen_HK
dc.contributor.authorJiao, XYen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorJu, Gen_HK
dc.contributor.authorYou, SWen_HK
dc.date.accessioned2010-09-25T16:10:09Z-
dc.date.available2010-09-25T16:10:09Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S90 Abstract no. P1-d37en_HK
dc.identifier.issn0168-0102en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95689-
dc.description.abstractAlthough olfactory ensheathing cells (OECs) have been successfully used to enhance axon regeneration within the injured central nervous system, no evidence could demonstrate any in vivo protective effect of such macroglial cells on injured central neurons. In the present study, we investigated the effect of OECs on neuronal survival of axotomized retinal ganglion cells (RGCs) in adult rats. OECs suspension or the same volume of DMEM/F12 medium was injected into the ocular stump of the orbitally transected ON in the experimental or control group. All animals were allowed to survive for 2, 7 or 14 days, respectively, following operation and the numbers of FluoroGold-labeled RGCs were counted. A significantly higher number (P < 0.01) was detected at 7 day in the experimental group than in the control group. Thus, transplanted OECs are capable of protecting injured RGCs at a certain period after ON transection.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuresen_HK
dc.relation.ispartofNeuroscience Researchen_HK
dc.rightsNeuroscience Research. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleNeuroprotective effects of transplanted olfactory ensheathing cells on axotimized retinal ganglion cells in adult ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-0102&volume=58S&spage=S90 P1&epage=d37&date=2007&atitle=Neuroprotective+effects+of+transplanted+olfactory+ensheathing+cells+on+axotimized+retinal+ganglion+cells+in+adult+ratsen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2007.06.1090-
dc.identifier.hkuros151794en_HK
dc.identifier.volume58en_HK

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