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Conference Paper: Neuroprotective polysaccharides from Nerium indicum rescue cultured neurons from beta-amyloid peptides-induced apoptosis via different mechanisms

TitleNeuroprotective polysaccharides from Nerium indicum rescue cultured neurons from beta-amyloid peptides-induced apoptosis via different mechanisms
Authors
Issue Date2007
PublisherSociety for Neuroscience. The abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings
Citation
37th Annual Meeting of the Society for Neuroscience. San Diego, CA, 3-7 November 2007. In Neuroscience 2007 Abstracts, Program#/Poster#: 169.8/DD9 How to Cite?
AbstractMost of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides. In this study, we have isolated and characterized a new polysaccharide from the flowers of N. indicum (named as J6) and aimed to investigate its neuroprotective effects against Aβ-induced apoptosis. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides in a dose-dependent manner. In contrast to the activation of survival signaling such as Akt found in J2, J3 and J4 fractions, the newly synthesized J6 markedly inhibited Aβ peptide-stimulated phosphorylation of c-Jun N-terminal kinase (JNK-1) as determined by western-blot analysis. Taken together, the polysaccharides isolated from the flowers of N. indicum can serve as potential neuroprotective agents against neuronal death in Alzheimer’s disease. The differences in neuroprotective mechanisms may due to the compositions of these polysaccharides; it would be investigated in the future study.
DescriptionSession: Poster: 169. Neuroprotective Mechanisms: Apoptosis and Caspases: Program#/Poster#: 169.8/DD9
Persistent Identifierhttp://hdl.handle.net/10722/95670

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorFang, JNen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T16:09:33Z-
dc.date.available2010-09-25T16:09:33Z-
dc.date.issued2007en_HK
dc.identifier.citation37th Annual Meeting of the Society for Neuroscience. San Diego, CA, 3-7 November 2007. In Neuroscience 2007 Abstracts, Program#/Poster#: 169.8/DD9en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95670-
dc.descriptionSession: Poster: 169. Neuroprotective Mechanisms: Apoptosis and Caspases: Program#/Poster#: 169.8/DD9-
dc.description.abstractMost of the polysaccharides purified from Chinese medicinal herbs showed anti-tumor and immune-stimulating effects. However, little is known about their effects on neuroprotection. Our previous study has demonstrated that polysaccharides (J2, J3 and J4) isolated from the flowers of Nerium indicum (Oleander) exert partial protection in cortical neurons stressed by beta-amyloid (Aβ) peptides. In this study, we have isolated and characterized a new polysaccharide from the flowers of N. indicum (named as J6) and aimed to investigate its neuroprotective effects against Aβ-induced apoptosis. Pretreatment of the polysaccharide J6 significantly decreased the activity of caspase-3 as well as the cytotoxicity triggered by Aβ peptides in a dose-dependent manner. In contrast to the activation of survival signaling such as Akt found in J2, J3 and J4 fractions, the newly synthesized J6 markedly inhibited Aβ peptide-stimulated phosphorylation of c-Jun N-terminal kinase (JNK-1) as determined by western-blot analysis. Taken together, the polysaccharides isolated from the flowers of N. indicum can serve as potential neuroprotective agents against neuronal death in Alzheimer’s disease. The differences in neuroprotective mechanisms may due to the compositions of these polysaccharides; it would be investigated in the future study.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleNeuroprotective polysaccharides from Nerium indicum rescue cultured neurons from beta-amyloid peptides-induced apoptosis via different mechanismsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.hkuros137984en_HK

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