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Conference Paper: Flk-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas

TitleFlk-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinas
Authors
Keywordsdevelopment
neurogenesis
immunohistochemistry
VEGF
Issue Date2003
PublisherSociety for Neuroscience
Citation
Neuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 453.12 How to Cite?
AbstractMembrane receptor tyrosine kinase Flk-1 (also designated VEGF-R2) is a high-affinity receptor for vascular endothelial growth factor (VEGF) and putatively involved in the growth of the vascualr endothelial cells. However, recently some researchers found that Flk-1 expresses in retinal progenitor cells of developmental mouse retinas and a role of VEGF for neural retinal development is implied. In the present study, we investigated the expression of Flk-1 and VEGF in the developmental human retinas ranging from 10.5 weeks of gestation (WG) to 22 WG by immunohistochemistry. We found that as early as 10.5 WG, Flk-1-immunoreactivity (IR) expresses in cell membrane of retinal progenitor cells of the inner retinas. At 17 WG, Flk-1-IR is expressed strongly in many cells of the ganglion cell layer and weakly in some cells at the innermost of inner nuclear layer. After 21 WG, Flk-1-IR is still expressed in cells of ganglion cell layer and most strongly in cells at innermost of inner nuclear layer and in addition, in horizontal cells. Flk-1-IR also expresses in choroid vessels outside the retinas at all stages, and in the retinal vessels after 18 WG. Meanwhile, VEGF-IR occurs in the Muller cells through all these time periods. In conclusion, we have shown the expression of Flk-1 in retinal progenitor cells and later on in neural retinal cells before retinal vessels occur in the retinas. Together with the consistent expression of VEGF in this developmental period, this study suggests that VEGF plays a nonvascular role for the development of human retinas. Supported by The University of Hong Kong, Research Grant Council of Hong Kong and Croucher Foundation
Persistent Identifierhttp://hdl.handle.net/10722/95658

 

DC FieldValueLanguage
dc.contributor.authorLi, Sen_HK
dc.contributor.authorShu, SYen_HK
dc.contributor.authorBao, XMen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorLui Kau, KWFen_HK
dc.contributor.authorLi, Fen_HK
dc.contributor.authorYang, WKen_HK
dc.contributor.authorYip, HKFen_HK
dc.date.accessioned2010-09-25T16:09:11Z-
dc.date.available2010-09-25T16:09:11Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 453.12-
dc.identifier.urihttp://hdl.handle.net/10722/95658-
dc.description.abstractMembrane receptor tyrosine kinase Flk-1 (also designated VEGF-R2) is a high-affinity receptor for vascular endothelial growth factor (VEGF) and putatively involved in the growth of the vascualr endothelial cells. However, recently some researchers found that Flk-1 expresses in retinal progenitor cells of developmental mouse retinas and a role of VEGF for neural retinal development is implied. In the present study, we investigated the expression of Flk-1 and VEGF in the developmental human retinas ranging from 10.5 weeks of gestation (WG) to 22 WG by immunohistochemistry. We found that as early as 10.5 WG, Flk-1-immunoreactivity (IR) expresses in cell membrane of retinal progenitor cells of the inner retinas. At 17 WG, Flk-1-IR is expressed strongly in many cells of the ganglion cell layer and weakly in some cells at the innermost of inner nuclear layer. After 21 WG, Flk-1-IR is still expressed in cells of ganglion cell layer and most strongly in cells at innermost of inner nuclear layer and in addition, in horizontal cells. Flk-1-IR also expresses in choroid vessels outside the retinas at all stages, and in the retinal vessels after 18 WG. Meanwhile, VEGF-IR occurs in the Muller cells through all these time periods. In conclusion, we have shown the expression of Flk-1 in retinal progenitor cells and later on in neural retinal cells before retinal vessels occur in the retinas. Together with the consistent expression of VEGF in this developmental period, this study suggests that VEGF plays a nonvascular role for the development of human retinas. Supported by The University of Hong Kong, Research Grant Council of Hong Kong and Croucher Foundation-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectdevelopment-
dc.subjectneurogenesis-
dc.subjectimmunohistochemistry-
dc.subjectVEGF-
dc.titleFlk-1, a receptor for vascular endothelial growth factor, is expressed in the neural cells of developmental human retinasen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailLui Kau, KWF: kwflui@HKUCC-COM.hku.hken_HK
dc.identifier.emailYip, HKF: hkfyip@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.hkuros87659en_HK

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