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Conference Paper: Erythropoietin exerts endogenous neuroprotection after ocular hypertension induced glaucoma and optic nerve transection injuries

TitleErythropoietin exerts endogenous neuroprotection after ocular hypertension induced glaucoma and optic nerve transection injuries
Authors
Issue Date2006
PublisherAssociation for Research in Vision and Ophthalmology.
Citation
The 2006 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL., 30 April-4 May 2006. In Investigative Ophthalmology & Visual Science, 2006, v. 47 n. 13, abstract no. 4806 How to Cite?
AbstractPurpose: Erythropoietin (EPO) has been viewed traditionally as a hematopoietic cytokine in response to hypoxia. Results of recent studies have showed that EPO plays an important role to protect neurons after central nervous system (CNS) injuries. Here we report the role of EPO/EPO–receptor (EPO–R) system in the rat retina after chronic ocular hypertension and acute optic nerve transection injuries. Methods: Experimental glaucoma was induced by elevating the intraocular pressure (IOP). Two times of laser photocoagulation were provided to the episcleral and limbal veins with 7days interval. We tested the effect of recombinant human EPO (rhEPO) on survival of retinal ganglion cells (RGCs) after ocular hypertension (chronic injury) and optic nerve transection (acute injury). Results: Systemic administration of rhEPO before and immediately after retinal injuries significantly reduced the loss of RGCs in the glaucoma model at 2 weeks after injury and also promoted the survival of RGCs at 1 week after optic nerve transection. We identified Müller cells as the main cellular source of EPO in the normal retina. The levels of EPO–R in the retina significantly increased at 2 weeks after ocular hypertension, especially in RGCs. Moreover, neutralization of endogenous EPO with soluble EPO–R exacerbated ocular hypertensive injury, which provides evidence supportive of an endogenous EPO/EPO–R system in the survival and recovery of RGCs after injury. Conclusions: This results indicate that an endogenous EPO/EPO–R system participate in intrinsic recovery mechanisms after retina injury and RGCs might be rescued by exogenous administration of EPO.
Persistent Identifierhttp://hdl.handle.net/10722/95641
ISSN

 

DC FieldValueLanguage
dc.contributor.authorFu, Qen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorHu, Ben_HK
dc.contributor.authorLee, VHen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-25T16:08:39Z-
dc.date.available2010-09-25T16:08:39Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 2006 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, FL., 30 April-4 May 2006. In Investigative Ophthalmology & Visual Science, 2006, v. 47 n. 13, abstract no. 4806en_HK
dc.identifier.issn1552-5783-
dc.identifier.urihttp://hdl.handle.net/10722/95641-
dc.description.abstractPurpose: Erythropoietin (EPO) has been viewed traditionally as a hematopoietic cytokine in response to hypoxia. Results of recent studies have showed that EPO plays an important role to protect neurons after central nervous system (CNS) injuries. Here we report the role of EPO/EPO–receptor (EPO–R) system in the rat retina after chronic ocular hypertension and acute optic nerve transection injuries. Methods: Experimental glaucoma was induced by elevating the intraocular pressure (IOP). Two times of laser photocoagulation were provided to the episcleral and limbal veins with 7days interval. We tested the effect of recombinant human EPO (rhEPO) on survival of retinal ganglion cells (RGCs) after ocular hypertension (chronic injury) and optic nerve transection (acute injury). Results: Systemic administration of rhEPO before and immediately after retinal injuries significantly reduced the loss of RGCs in the glaucoma model at 2 weeks after injury and also promoted the survival of RGCs at 1 week after optic nerve transection. We identified Müller cells as the main cellular source of EPO in the normal retina. The levels of EPO–R in the retina significantly increased at 2 weeks after ocular hypertension, especially in RGCs. Moreover, neutralization of endogenous EPO with soluble EPO–R exacerbated ocular hypertensive injury, which provides evidence supportive of an endogenous EPO/EPO–R system in the survival and recovery of RGCs after injury. Conclusions: This results indicate that an endogenous EPO/EPO–R system participate in intrinsic recovery mechanisms after retina injury and RGCs might be rescued by exogenous administration of EPO.-
dc.languageengen_HK
dc.publisherAssociation for Research in Vision and Ophthalmology.-
dc.relation.ispartofInvestigative Ophthalmology & Visual Scienceen_HK
dc.titleErythropoietin exerts endogenous neuroprotection after ocular hypertension induced glaucoma and optic nerve transection injuriesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailHu, B: bhu@ustc.edu.cnen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros116530en_HK

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