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Conference Paper: Age-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomy

TitleAge-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomy
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
The 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S11 How to Cite?
AbstractThis study examined the expression of nestin in the neurohypophyseal system during the development and after hypophysectomy. The potential role of nestin expression in both normal developing and following injury was also studied. In normal non-injured and sham operated animals, the distribution of nestin positive cells changes with ages. At postnatal day 1 (P1) nestin positive cells and fibers present densely in almost all areas of the hypothalamus. In adult animals, nestin posive cells and fibers are restricted to a narrow area, including the walls of the third ventricle and median eminence (ME). Following hypophysectomy in developing (P14) rats, the expression of nestin slightly increases in both the supraoptic nucleus (SON) and the paraventricular nucleus (PVN). The nestin positive cells display appearance of stellate-shaped astrocytes. In contrast, following hypophysectomy in adult rats, the expression of nestin significantly increases. Strongly immonostained nestin positive cells are observed in SON by 1 week, peak at 2 weeks, and persist for at lease 4 weeks post-injury. These nestin positive cells are glialike cells that exhibit elongated processes, morphologically compatible with radial glia. Moreover, some nestin positive cells are also detected in the posterior part of paraventricular nucleus (PVN) which display appearance of stellate-shaped astrocytes. There is no obvious increase of nestin immunoreactivity in both the walls of the third ventricle and ME in both P14 and adult animals following hypophysectomy as compared with the corresponding sham operated controls. The age- and region-dependent alterations of nestin immunoreactivity in response to the hypophysectomy in hypothalamoneurohypophyseal system may be critical in modulating neural repair and regeneration after hypophysectomy.
Persistent Identifierhttp://hdl.handle.net/10722/95564
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-25T16:06:14Z-
dc.date.available2010-09-25T16:06:14Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S11en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95564-
dc.description.abstractThis study examined the expression of nestin in the neurohypophyseal system during the development and after hypophysectomy. The potential role of nestin expression in both normal developing and following injury was also studied. In normal non-injured and sham operated animals, the distribution of nestin positive cells changes with ages. At postnatal day 1 (P1) nestin positive cells and fibers present densely in almost all areas of the hypothalamus. In adult animals, nestin posive cells and fibers are restricted to a narrow area, including the walls of the third ventricle and median eminence (ME). Following hypophysectomy in developing (P14) rats, the expression of nestin slightly increases in both the supraoptic nucleus (SON) and the paraventricular nucleus (PVN). The nestin positive cells display appearance of stellate-shaped astrocytes. In contrast, following hypophysectomy in adult rats, the expression of nestin significantly increases. Strongly immonostained nestin positive cells are observed in SON by 1 week, peak at 2 weeks, and persist for at lease 4 weeks post-injury. These nestin positive cells are glialike cells that exhibit elongated processes, morphologically compatible with radial glia. Moreover, some nestin positive cells are also detected in the posterior part of paraventricular nucleus (PVN) which display appearance of stellate-shaped astrocytes. There is no obvious increase of nestin immunoreactivity in both the walls of the third ventricle and ME in both P14 and adult animals following hypophysectomy as compared with the corresponding sham operated controls. The age- and region-dependent alterations of nestin immunoreactivity in response to the hypophysectomy in hypothalamoneurohypophyseal system may be critical in modulating neural repair and regeneration after hypophysectomy.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleAge-dependent induction of nestin expression in paraventricular and supraoptic nuclei after hypophysectomyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=370 Supplement&spage=S11&epage=&date=2004&atitle=Age-dependent+induction+of+nestin+expression+in+paraventricular+and+supraoptic+nuclei+after+hypophysectomyen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2004.09.001-
dc.identifier.hkuros108005en_HK
dc.identifier.volume370en_HK
dc.identifier.spageS11en_HK

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