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Conference Paper: Neuroprotective effects of methylated resveratrols in an in vitro Parkinson’s disease model

TitleNeuroprotective effects of methylated resveratrols in an in vitro Parkinson’s disease model
Authors
KeywordsParkinson's Disease
6-Hydroxydopamine
Methylated Resveratrol
Issue Date2009
PublisherSociety for Neuroscience.
Citation
The 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009 How to Cite?
AbstractEmerging lines of evidence have supported the beneficial effects of methylated resveratrol derivatives on cardiovascular systems. However, little is known about the effects of its derivatives on the development of Parkinson’s disease (PD). In this study, the neuroprotective effects of resveratrol and four methylated resveratrol derivatives against parkinsonian mimetic 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells were compared. Lactate dehydrogenase release and caspase-3 activity triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, pinostilbene (3,4’-dihydroxy-5-methoxystilbene) in a dose-dependent manner, exerting potent neuroprotective effects with a wider effective concentration range than resveratrol. In addition, high performance liquid chromatography showed significantly higher uptake of pinostilbene into SH-SY5Y cells than that of resveratrol. The enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of pinostilbene. Moreover, Western-blot analysis demonstrated that pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Mammalian target of rapamycin kinase may also be an intracellular target responsible for the neuroprotective effects of pinostilbene. Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.
DescriptionPoster session: 144.Parkinson's Disease: Cellular Mediation
Program no. 144.2 & Poster no. G10
Persistent Identifierhttp://hdl.handle.net/10722/95562

 

DC FieldValueLanguage
dc.contributor.authorChao, Jen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorCheng, KWen_HK
dc.contributor.authorYu, MSen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T16:06:10Z-
dc.date.available2010-09-25T16:06:10Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95562-
dc.descriptionPoster session: 144.Parkinson's Disease: Cellular Mediation-
dc.descriptionProgram no. 144.2 & Poster no. G10-
dc.description.abstractEmerging lines of evidence have supported the beneficial effects of methylated resveratrol derivatives on cardiovascular systems. However, little is known about the effects of its derivatives on the development of Parkinson’s disease (PD). In this study, the neuroprotective effects of resveratrol and four methylated resveratrol derivatives against parkinsonian mimetic 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells were compared. Lactate dehydrogenase release and caspase-3 activity triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, pinostilbene (3,4’-dihydroxy-5-methoxystilbene) in a dose-dependent manner, exerting potent neuroprotective effects with a wider effective concentration range than resveratrol. In addition, high performance liquid chromatography showed significantly higher uptake of pinostilbene into SH-SY5Y cells than that of resveratrol. The enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of pinostilbene. Moreover, Western-blot analysis demonstrated that pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Mammalian target of rapamycin kinase may also be an intracellular target responsible for the neuroprotective effects of pinostilbene. Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofNeuroscience 2009en_HK
dc.rightsNeuroscience 2009. Copyright © Society for Neuroscience.-
dc.subjectParkinson's Disease-
dc.subject6-Hydroxydopamine-
dc.subjectMethylated Resveratrol-
dc.titleNeuroprotective effects of methylated resveratrols in an in vitro Parkinson’s disease modelen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChao, J: jfchao@hku.hken_HK
dc.identifier.emailLi, H: zhen_xi0315@yahoo.com.hken_HK
dc.identifier.emailCheng, KW: h0235211@hkusua.hku.hken_HK
dc.identifier.emailYu, MS: ymsmabel@graduate.hku.hken_HK
dc.identifier.emailWang, M: mfwang@hkusua.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros168094en_HK
dc.publisher.placeUnited States-

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