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Conference Paper: Neuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi)

TitleNeuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi)
Authors
Keywordsaging
Alzheimer’s disease
amyloid
apoptosis
neuroprotection
Issue Date2004
PublisherWiley-Blackwell Publishing Ltd.
Citation
The 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, 4-7 February 2004. In Journal of Neurochemistry, 2004, v. 88 n. S1, p. 69 Abstract no. P26-21 How to Cite?
AbstractRecent findings demonstrated that extracts from Lycium barbarum (Gou-Qi-Zi) exhibit anti-aging effects. It is hypothesized that these extracts exhibitneuroprotective effects against toxins in aging-related neurodegenerativediseases. In this study, we aim to investigate whether extracts fromL. barbarum have neuroprotective effects against beta-amyloid (Ab) peptidestoxicity. Rat cortical neurons exposed to Ab peptides resulted in apoptosisand subsequent necrosis. Pretreatment of aqueous or alkaline extractssignificantly reduced the release of lactate dehydrogenase. In addition, theyattenuated Ab peptide-induced caspases-3 and -2. While the aqueous extractelicited a typical dose-dependent neuroprotective effect, the alkaline extractshowed bi-phasic responses. Potential therapeutic window of using aqueousextract was wider than that of a well-known Western medicine LiCl. We havefurther examined the underlying mechanisms of neuroprotection. Pretreat-ment of aqueous extract markedly reduced the Ab peptide-stimulatedphosphorylation of JNK-1 and its substrates c-Jun-I and c-Jun-II. Takentogether, we have proved our hypothesis by showing neuroprotective effectsof the extracts from L. barbarum. Since Ab neurotoxicity plays significantroles in aging-related Alzheimer’s disease (AD), extracts from L. barbarummay open a new therapeutic window for the prevention of AD.
Persistent Identifierhttp://hdl.handle.net/10722/95527
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T16:05:04Z-
dc.date.available2010-09-25T16:05:04Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 6th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, Hong Kong, 4-7 February 2004. In Journal of Neurochemistry, 2004, v. 88 n. S1, p. 69 Abstract no. P26-21en_HK
dc.identifier.issn0022-3042en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95527-
dc.description.abstractRecent findings demonstrated that extracts from Lycium barbarum (Gou-Qi-Zi) exhibit anti-aging effects. It is hypothesized that these extracts exhibitneuroprotective effects against toxins in aging-related neurodegenerativediseases. In this study, we aim to investigate whether extracts fromL. barbarum have neuroprotective effects against beta-amyloid (Ab) peptidestoxicity. Rat cortical neurons exposed to Ab peptides resulted in apoptosisand subsequent necrosis. Pretreatment of aqueous or alkaline extractssignificantly reduced the release of lactate dehydrogenase. In addition, theyattenuated Ab peptide-induced caspases-3 and -2. While the aqueous extractelicited a typical dose-dependent neuroprotective effect, the alkaline extractshowed bi-phasic responses. Potential therapeutic window of using aqueousextract was wider than that of a well-known Western medicine LiCl. We havefurther examined the underlying mechanisms of neuroprotection. Pretreat-ment of aqueous extract markedly reduced the Ab peptide-stimulatedphosphorylation of JNK-1 and its substrates c-Jun-I and c-Jun-II. Takentogether, we have proved our hypothesis by showing neuroprotective effectsof the extracts from L. barbarum. Since Ab neurotoxicity plays significantroles in aging-related Alzheimer’s disease (AD), extracts from L. barbarummay open a new therapeutic window for the prevention of AD.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.en_HK
dc.relation.ispartofJournal of Neurochemistryen_HK
dc.rightsJournal of Neurochemistry. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectaging-
dc.subjectAlzheimer’s disease-
dc.subjectamyloid-
dc.subjectapoptosis-
dc.subjectneuroprotection-
dc.titleNeuroprotective effects of extracts from anti-aging chinese medicine Lycium Barbarum (Gou-Qi-Zi)en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3042&volume=88 Suppl. 1&spage=69 No.P26&epage=21&date=2004&atitle=Neuroprotective+effects+of+extracts+from+anti-aging+chinese+medicine+Lycium+Barbarum+(Gou-Qi-Zi)en_HK
dc.identifier.emailYu, MS: ymsmabel@graduate.hku.hken_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1474-1644.2003.2314p26_01.x-
dc.identifier.hkuros85902en_HK
dc.identifier.volume88en_HK
dc.identifier.spage69en_HK
dc.identifier.epage69en_HK

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