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Conference Paper: Immortalization of nasopharyngeal epithelial cells and their applicatons in EBV study

TitleImmortalization of nasopharyngeal epithelial cells and their applicatons in EBV study
Authors
Issue Date2006
PublisherInternational Association for Research on Epstein-Barr Virus and Associated Diseases.
Citation
The 12th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, Boston/Cambridge, MA., 8-12 July 2006. In Final Program and Abstracts, 2006, p. 273 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a common disease in Hong Kong and Southern provinces of China, and is closely associated with Epstein-Barr virus (EBV) infection. Immortalized nasopharyngeal epithelial cell system with well-characterized properties will be useful in elucidation the role of EBV infection in NPC. Our laboratories have been involved in the establishment and characterization of immortalized nasopharyngeal epithelial cells using telomerase, SV40T and HPV16E6E7. These immortalized cell lines resemble and share many properties of premalignant nasopharyngeal epithelial cells. The NP69 cells(immortalized by SV40T) could be infected by EBV and highly responsive to the transformation property of EBV oncogenes including LMP1. Recently, we have established a near diploid nasopharyngeal epithelial cell line (NP460) using telomerase alone. The NP460 is unique in haboring a discrete deletion of p16 and RASSF1A inactivation. The properties of these immortalized nasopharyngeal epithelial cell lines and their applications in EBV studies will be presented.
Persistent Identifierhttp://hdl.handle.net/10722/95457

 

DC FieldValueLanguage
dc.contributor.authorTsao, GSW-
dc.contributor.authorMan, CWY-
dc.contributor.authorLi, HM-
dc.contributor.authorYip, YL-
dc.contributor.authorTsang, CM-
dc.contributor.authorLo, KW-
dc.contributor.authorLo, AKF-
dc.contributor.authorWu, ZG-
dc.contributor.authorZeng, MS-
dc.contributor.authorZeng, YX-
dc.date.accessioned2010-09-25T16:02:52Z-
dc.date.available2010-09-25T16:02:52Z-
dc.date.issued2006-
dc.identifier.citationThe 12th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, Boston/Cambridge, MA., 8-12 July 2006. In Final Program and Abstracts, 2006, p. 273-
dc.identifier.urihttp://hdl.handle.net/10722/95457-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a common disease in Hong Kong and Southern provinces of China, and is closely associated with Epstein-Barr virus (EBV) infection. Immortalized nasopharyngeal epithelial cell system with well-characterized properties will be useful in elucidation the role of EBV infection in NPC. Our laboratories have been involved in the establishment and characterization of immortalized nasopharyngeal epithelial cells using telomerase, SV40T and HPV16E6E7. These immortalized cell lines resemble and share many properties of premalignant nasopharyngeal epithelial cells. The NP69 cells(immortalized by SV40T) could be infected by EBV and highly responsive to the transformation property of EBV oncogenes including LMP1. Recently, we have established a near diploid nasopharyngeal epithelial cell line (NP460) using telomerase alone. The NP460 is unique in haboring a discrete deletion of p16 and RASSF1A inactivation. The properties of these immortalized nasopharyngeal epithelial cell lines and their applications in EBV studies will be presented.-
dc.languageeng-
dc.publisherInternational Association for Research on Epstein-Barr Virus and Associated Diseases.-
dc.relation.ispartofBiennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases-
dc.titleImmortalization of nasopharyngeal epithelial cells and their applicatons in EBV study-
dc.typeConference_Paper-
dc.identifier.emailTsao, GSW: gswtsao@hkucc.hku.hk-
dc.identifier.emailMan, CWY: cornman@hkucc.hku.hk-
dc.identifier.emailYip, YL: elaineyip@graduate.hku.hk-
dc.identifier.emailTsang, CM: anna0226@graduate.hku.hk-
dc.identifier.authorityTsao, GSW=rp00399-
dc.identifier.authorityTsang, CM=rp01964-
dc.identifier.hkuros160593-
dc.identifier.spage273-
dc.identifier.epage273-
dc.publisher.placeUnited States-

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